A trifecta of wipeouts for major CAM modalities this week…

It’s been another interesting week for those who follow the literature on CAM.

To start off there is this article which is a big and well-conducted meta-analysis of Omega-3 supplementation in cardiac prevention. Even at a glance, it is apparent that the methodological niceties have been observed, since three very important comments are made up front. Firstly, the numbers are very big (over 68,000 patients in the studies analyzed). Secondly, they used 20 large studies for comparison and have included robust assessments of the heterogeneity of the studies involved. This is very important in a meta-analysis since in basic terms it accounts for the fact that different methodologies can give different answers, and different populations under study will also give variable results. Using fairly rarefied stats techniques one can compare across studies with some degree of confidence. The third piece of crucial information is to note that they have accounted for multiple comparisons. This is important because if you are performing lots of analyses, you will get some correlations as a matter of chance. The more comparisons, the more likely you are to come up with statistically significant correlations which disappear in subsequent studies. Any study which uses multiple regression techniques to get at hidden secrets in the data has to report that they have adjusted for multiple comparisons, and these authors have done just that.

So even before getting past the abstract, this looks like a credible study. It demonstrates pretty comprehensively that Omega 3 supplements aren’t effective at preventing cardiac problems like heart attacks, stroke, sudden death and arrhythmias. What makes this study more credible is that it has included both dietary and supplement studies. So whether you are getting your Omega 3’s from a capsule or from tins of tuna, it seems unlikely based on this very large and convincing study that they are doing much good.

The Cochrane Back Group has just released an updated systematic review of spinal manipulation therapy for acute low back pain (LBP). ‘Acute’ back pain by definition is pain which has been around for less than 6 weeks. The natural history of acute LBP is that 80% is better by 8 weeks, and half of the remaining patients get better over the next 8 weeks. This is a condition which has a high rate of spontaneous recovery over a couple of months no matter how agonisingly painful it is for the first couple of weeks. It is therefore not an easy condition to show a definite benefit for any proposed treatment. Unsurprisingly, there is no robustly evidence-based treatment for acute LBP apart from avoiding bed rest as much as possible. On the background of this lack of really effective treatments, manipulative therapists such as chiropractors and osteopaths have gained some acceptance while better evidence was awaited. The Cochrane acute LBP review of spinal manipulative therapy (SMT) was last updated in 2004. The new review includes 12 trials in addition to the 8 available in the previous review. The authors note that they included trials from the manual therapy, chiropractic and osteopathic literature in their search. Their conclusions deserve to be quoted in full..

“In this review, a total of 20 randomized controlled trials (RCTs) (representing 2674 participants) assessing the effects of SMT in patients with acute low-back pain were identified. Treatment was delivered by a variety of practitioners, including chiropractors, manual therapists, and osteopaths. Approximately one-third of the trials were considered to be of high methodological quality, meaning these studies provided a high level of confidence in the outcome of SMT.

Overall, we found generally low to very low quality evidence suggesting that SMT is no more effective in the treatment of patients with acute low-back pain than inert interventions, sham (or fake) SMT, or when added to another treatment such as standard medical care. SMT also appears to be no more effective than other recommended therapies. SMT appears to be safe when compared to other treatment options but other considerations include costs of care"

So that’s two strikes for two very popular and widespread CAM modalities. The third leg of the trifecta is this study in the prestigious Annals of Internal Medicine journal.

On the face of it, this looks to be a definite plus in favour of acupuncture for chronic pain conditions, but it simply isn’t what it appears. The abstract doesn’t report heterogeneity analysis, neither does it report adjusting for multiple comparisons. Both these deficiencies reduce your confidence in the strength of the conclusions. They are also just reporting pain scores, not pain-related disability or other functional goals. But let’s not quibble. Let’s suspend routine critical thinking and give them a pass on this. What are they actually reporting?

“Significant differences between true and sham acupuncture indicate that acupuncture is more than a placebo. However, these differences are relatively modest, suggesting that factors in addition to the specific effects of needling are important contributors to the therapeutic effects of acupuncture.”

The actual effect size they are reporting as ‘modest’ is actually more like ‘negligible’ when talking about chronic pain. Although it might be statistically significant, it is too small a difference to be clincially signficant. They are reporting with a straight face that 80% or so of the benefit of acupuncture that they have been able to torture out of the data is in fact not due to the specific effects of putting the needle in.

Slap me if I’m being thick here, but isn’t careful placement of the needle into the strictly defined acupoint the whole thing acupuncture is meant to be about? If this was a Big Pharma drug trial it would be wipeout that would probably precipitate a marked decline in prescriptions.

If that is the best possible result they can get by disregarding the usual standards of a meta-analysis, I think I’ll be referring my patients for a cup of tea and a chat with my mum before I send them for acupuncture, since the majority of the benefit comes from having a charismatic and sympathetic listener.

PS. I’m kidding about the referrals bit Mum, not the other bit!

BREAKING NEWS

My copy of Pain has just dropped through the letterbox and it contains another 2 acupuncture-related articles of relevance. This one is a test of acupuncture analgesia on human experimentally-induced pain using both sham and real acupuncture needles. It showed no useful effect in any of the usual tests of effective analgesia.

The other was a very tightly designed RCT in acute LBP, comparing usual care with placebo acupuncture (ie placing needles in the ‘wrong’ spots), sham acupuncture (using retractable needles) and real acupuncture (done according to TCM principles). Regular readers will be able to guess the result.

Yep, you guessed it.

All 3 acupuncture arms did slightly better than the ‘conventional treatment’ arm, but not any better than each other. Confirming again that acupuncture is a strongly context-based treatment where the needles are essentially a prop.

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43 Comments sorted by

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  1. Laurie Willberg

    Journalist

    "SMT also appears to be no more effective than other recommended therapies." It doesn't appear to be any LESS effective either, and no mention of what those "other recommended therapies" are exactly but are probably NSAIDS that cause liver damage.
    I'll wait for the Orthomolecular Medicine Journal to comment on the Omega 3 study, which more likely than not cherry picked the data convenient to the researchers' bias, used the wrong type of Omega 3 (flax oil) and/or did not use therapeutic doses…

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    1. Virgin Jared

      logged in via Twitter

      In reply to Laurie Willberg

      A great demonstration of cherry picking.. Opening sentence. Completely missed the "[SMT also appears to be no more effective than].... inert interventions, sham (or fake) SMT"

      Sham spinal manipulation and inert interventions (doing nothing).
      (Spinal manipulation is no better than fake manipulation or doing nothing..)

      Unless you manipulate the sentences to exclude parts of the discussion that you don't like.

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    2. Ian Musgrave

      Senior lecturer in Pharmacology at University of Adelaide

      In reply to Laurie Willberg

      Or you could read the actual study.
      "omega-3 PUFA supplements were used; the mean omega-3 dose was 1.51 g per day (0.77-g/d eicosapentaenoic acid [EPA], 0.60-g/d docosahexaenoic acid [DHA]), while 10 studies used an omega-3 dose of 1 g or greater per day. The median treatment duration was 2 years (maximum, 6.2 years5 )"

      And they also looked at studies with actual fish consumption.

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    3. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to Laurie Willberg

      Actually Laurie, it's the conclusion that acupuncture was shown to be effective that doesn't fit the body of the analysis. In pain medicine it is an accepted convention that clinical significance is at least 2 points of difference on a 10-point Numerical Rating Scale , or 20mm on the 100mm Visual Analogue Scale. The effect size they are reporting (bearing in mind that there is some fairly questionable methodology which we are waving through for brevity's sake) is less than this. It therefore is not clinically relevant, even if the statistical methods were impeccable. In translating huge meta-analyses like this into real-life practice, you are looking at fairly pure evidence of efficacy. You cannot translate this type of finding into a blanket statement about any given individual.

      I too will await the interpretation of the denizens of the Orthomolecular Medicine world, because it's bound to be very instructive.

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  2. Greg Horgan

    The Bush Philosopher

    It's pretty clear what your agenda is. I wonder whether you would be happy to now go and apply the same analytic te hnique to your own brand of therapy. Maybe your mum migh want to take that cup of tea with sugar, smile and leave it up to the gods.

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    1. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Greg Horgan

      "I wonder whether you would be happy to now go and apply the same analytic technique to your own brand of therapy." - I think you'll find it already has been so applied. It's called medical science i.e. the only methodology in human history that has given us any significant ability to intervene in complex physiological processes at all.

      A piece of friendly advice from one philosopher to another: Philosophy isn't rhetoric. You make no attempt here to argue against anything Dr. Vagg actually wrote. If you want to keep calling yourself a philosopher (armchair or otherwise) you'll need to do better than that. We expect certain standards within this discipline, whatever furniture may happen to be involved. So if you have rebuttals to offer of specific points in Dr. Vagg's article, please share them.

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    2. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to Greg Horgan

      Greg, thanks for your comment but I hope you're not going to leave it there.

      I think we'd all like to hear your take on what my agenda is.

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    3. Ian Musgrave

      Senior lecturer in Pharmacology at University of Adelaide

      In reply to Michael Vagg

      It's probably very much like my agenda:
      08:30 – 09:00 First coffee of the day, deal with administriva
      09:00 – 10:00 Write Workshop assessment response
      10:00 – 11:00 EP Honours project review
      11:00 - 11:10 Coffee
      11:10 – 12:00 Herbal Group project data review
      12:00 – 12:30 Vacation Scholarship interview
      12:30 – 13:30 Insecticide Honours project review
      13:00 – 14:00 e-Learning demonstration
      14:00 – 14:10 COFFEE!!!
      14:00 – 16:00 Co-ordinate and assess Environment Students workshop
      15:30 – 16:30 Review Med Students Research project proposal
      16:30 – 17:00 Honours course administration




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    4. Grendelus Malleolus

      Senior Nerd

      In reply to Ian Musgrave

      Such lovely variety in your day!

      7.00 -7.30 - Coffee (2 long blacks and a Ristretto)

      7.30 - 8.00 - team meeting

      8.00 - 10.00 - teleconference with colleagues interstate on grant funding allocations

      10.00 - 11.30 - Managment team meeting

      11.30 - 13.30 - Data release review

      13.30 - 13.45 - lunch

      14.00 - 15.00 CEO briefing on national program

      15.00 - 17.00 Research Program review.

      Yup, Thursday is meeting day. I like Ian's agenda better than mine.

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  3. Dania Ng

    Retired factory worker

    Yep. Unfortunately, Vagg has been caught twisting facts (that is, making things up as he goes along) before, like for instance here: https://theconversation.edu.au/ersatz-science-does-not-help-inform-debate-about-social-policy-6893

    You see, Vagg is a practicing skeptic. Not just the kind of skeptic who uses facts in an unbiased way, but one that only chooses to use SOME facts, and in particular arrangements - you know, the facts which suit his agenda arraigned in particular ways to most effectively downplay anything that is not his kind of simplistic science.

    Yep, I think we will take up your invitation to slap you for being thick, Vaggy-mate. For my buck, I would rather ask: why do people still choose to use non-Western health care services, despite the hold on [mis]information your kind has in publications like this one?

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    1. Virgin Jared

      logged in via Twitter

      In reply to Dania Ng

      Another practicing skeptic calls you out Dania, for your use of ad hominem attacks on the author. It's fine to point out a flaw in an argument. The task you have then is pointing out exactly what was wrong? Throwing bullets into the air never won a war.

      Seems the only point you have is an argument via popularity. Why do people still use alt-med in spite of the evidence against it?

      A very good question. If the only reason is that so many other people are using it, then we run the risk of dragging out an old cliche about a cliff..

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    2. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Dania Ng

      Do you actually have any specific scientific or methodological objections to anything he says in the article? Or do you just want to keep making unsupported assertions about the reliability of the author?

      You ask: "Why do people still choose to use non-Western health care services"? Here's one hypothesis: Because we're desperate. Because when "here's the best that the only successful explanatory framework we have for dealing with physical reality can do for you at this point in its history" doesn't solve the problem, we'll reach for anything that claims it can. And we'll cling to the belief it's helping regardless of what empirical observation says. Because we want to believe that somewhere out there there's an answer to our problem. Because we fear illness and death and don't want to accept how (relatively) powerless we are in the face of them. That seems a more parsimonious explanation than the alternatives that have been offered.

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    3. Ian Musgrave

      Senior lecturer in Pharmacology at University of Adelaide

      In reply to Dania Ng

      The whole point of a meat analysis is to look at the totality of the facts, and when an enormous meta analysis cannot find an effect (eg omega 3) or a no more than a minute, clinically insignificant effect (acupuncture), then you have to take note of this and not attack the messenger.

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    4. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to Dania Ng

      Dania,
      your contributions would be more welcome if they had some type of point that was related to the content of the article you were 'commenting' on. This isn't Reddit.

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    5. Dania Ng

      Retired factory worker

      In reply to Michael Vagg

      The point is that your view and ability to be objective rather than carry an agenda has been discredited in this here publication (link in my previous posting), that's one eminently relevant point to your article, Michael. But if you really wish some sort of a specific point 'relevant' to your article, how about you do some background reading on meta-analysis and acknowledging the problematic nature of this methodology, which Fenistein referred to as 'statistical alchemy for the 21st century' (in…

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    6. Grendelus Malleolus

      Senior Nerd

      In reply to Dania Ng

      Dania, the document you linked to supports the use of meta-analysis. It addresses each of the criticisms that were raised. The fact that Feinstein stated that 'statistical alchemy for the 21st century' says more about the weakness of their addiction to telling allegorical stories than it is a real flaw in meta analyses.

      Your attempt at the swan analogy is confusing in this context - were you in fact meaning to use Taleb's Black Swan theory? In any case I feel the analogy is incorrect because science, even when making assumptions, does not ignore the evidence of the existence of black swans when thwt existence is demonstrated.

      Note, I'm attacking your arguements, not you.

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    7. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to Dania Ng

      Thankyou for clarifying Dania

      Since you profess not to wish to engage with me, I assume you will confine yourself to posting similar confused conflations of Kuhn and Popper in future. Lemme know if you want to understand meta-analysis before just googling it and linking to something you haven't read.

      I am still a little mystified as to the serious questions about my scholarship to which you refer. I thought my piece about the fake science behind the so-called Doctors for the Family submission is fairly self-explanatory.

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    8. Dania Ng

      Retired factory worker

      In reply to Patrick Stokes

      Patrick, a hypothesis is not what you describe. Do you instead mean a reason as to why we turn to other forms of health care? There's certainly the desperation factor for some people. But there is also the brainwashing, the marketing of modern medicine, the often de-humanised, cold and arrogant treatment at the hand of doctors and other medical professionals which makes us turn to other health care services. It is called hope, and humanity. A holistic approach, rather than a coldly clinical one - one that takes time to view you as an individual who is ill or has been harmed, and not as a 7.5 minute appointment. To see the kind of hyperbole Vagg and others are peddling here in order to discredit anything else that can give that kind of care is really sad. It is really simple: they want us to rely entirely on their brand of western medicine - anything else just won't do. In other words, they want us not to have access to anything else but their 7.5 minute appointments.

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    9. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Dania Ng

      I looked at Dr. Vagg's previous Conversation piece - can you point me to where he is 'discredited'? I take it you aren't basing your entire dismissal of his expert opinion on 'Dan Nobull's' post are you?

      In any case, your swan analogy doesn't quite make the point you want it to make - it's simply an illustration of how inductive reasoning works, not an illustration of Kuhnian revolutions. Finding a black swan invalidates the inductive conclusion that all swans are white, but that doesn't bring about a 'paradigm shift' (to use a Kuhnian terms that has been horribly misappropriated by every management guru since) of the sort Kuhn was interested in.

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    10. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Dania Ng

      Leaving aside the probably unfair generalisations about doctors (most doctors I've been to have been pretty 'holistic' in the sense of focusing on the overall health of the patient, and haven't rushed me out the door in 7.5 minutes either), the big problem here is that "hope and humanity" aren't much good if the treatment doesn't actually work. With regard to medical treatment, success will be wholly a matter of a physical (in this case organic) entity responding in the desired physical ways to particular physical interventions. And we have precisely one successful way of objectively measuring what physical reality is doing, and that's science.

      For the non-physical (metaphysical, moral, aesthetic etc.) issues, there's people like me. But we can't make tumors shrink or arteries unblock. When your car breaks down you don't take it to a psychiatrist, so why take your body to someone who has shown no demonstrated ability to fix it?

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    11. Dania Ng

      Retired factory worker

      In reply to Patrick Stokes

      Okay Patrick. I think you've forgetton what the endeavour of human inquiry is. Aristotle outlined three dimensions to it: episteme, techne and phronesis. Modernity focuses on the first two, forgetting the latter. Some of us argue that this leads to a kind of mechanistic society, where subjectivity (what makes us human) is forever attacked and used against individuals. We are seldom allowed to challenge anything that stems from the domain of the former two, and especially from the first. A special…

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    12. Dania Ng

      Retired factory worker

      In reply to Patrick Stokes

      Patrick, you don't have to believe anyone, but you can simply follow Dan Nobull's 'methodology' (you know, replicate what he has done - like in good scientific practice), or you can simply test the argument, if you'd like a philosophical approach. As I read it, here is what he found:
      Vagg,
      - said a fluffy about locating the doctors' submission
      - said another fluffy about being unable to locate particular literature (how naive does he think we are?)
      - said another fluffy about a very significant…

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    13. Dave Hawkes

      Research Officer (Viral tools and Neuropeptides) at The Florey Institute of Neuroscience and Mental Health

      In reply to Dania Ng

      Ummm You kind of lost me there. Science is a method, it is used to examining the natural world. You are not required to utilise this resource. Feel free to refuse vaccinations, antibiotics, etc. None of those things are compulsory in Australia. I have no problem with people choosing to use homeopathy, or iridology or any other CAM therapy. I don't think I should pay (through taxes) for something which is no shown to work (I am even comfortable with not knowing the mechanism, if 100 people are given…

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    14. Grendelus Malleolus

      Senior Nerd

      In reply to Dania Ng

      "why should I invest more time in this, only to be patronised with comments like these"

      So responding politely is now patronising.

      That is going to make online debate rather ridiculous.

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    15. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Dania Ng

      While I enjoyed the Foucaultian resonances of your post, phronesis i.e. practical wisdom doesn't really seem to be the issue here. The importance (and irreducibility) of subjectivity and the centrality of moral experience are core parts of my research work, so I'm certainly not dismissing them. And obviously there's a range of moral and experiential issues *surrounding* medicine that are extremely important. Whether to continue an invasive treatment for a terminal illness or enjoy whatever time is…

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    16. Patrick Stokes

      Lecturer in Philosophy at Deakin University

      In reply to Dania Ng

      Seeing as you are apparently basing your views of Dr Vagg's credibility on Dan Nobull's post, let's go through the claims you're relying on. In your summary, Vagg:

      1. "said a fluffy about locating the doctors' submission"

      He said it wasn't easy to find. Without having the webpages of both Doctors for Families and the Senate inquiry as they appearted at the time Dr. Vagg wrote his piece I have no way of assessing that; however at worst it means he didn't see the link. If you go to the website…

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    17. Dania Ng

      Retired factory worker

      In reply to Patrick Stokes

      It seems that both you, Patrick, and David previously, misunderstood what I was saying. I am certainly not against science, nor against medicine - far from it! But it doesn't rule my thinking to the exception of everything else - for me it is simply one set of tools which enables me to understand objective reality. It has no special place in my moral thinking. My original posting was intended to make the point that many use science to advance ideological agenda, and to hide behind it for reasons…

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    18. Dania Ng

      Retired factory worker

      In reply to Patrick Stokes

      Thanks Patrick for the comprehensive reply, kudos to you for taking up my challenge to check that stuff out.
      I don't agree with most of the arguments you raised, as follows:
      1. Sorry, but that's just poppycock - one only has to scroll down about a quarter of mouse wheel, that's all. And you forgot to mention that above the relevant link on the dr4marriage's website there is this statement: "28 March 2012 can be found under News or at submission 229 at [URL]". But regardless of this, I am not…

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    19. Dania Ng

      Retired factory worker

      In reply to Dave Hawkes

      Please stay lost, David. But in case you wish to engage in an intelligent discussion, please see my response to Patrick, below. Whilst you're deciding, maybe read some more eugenics? it seems right down your alley (if you don't understand what I mean, that's tough luck).

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  4. jerry sprom

    logged in via email @gmail.com

    Hi Michael,
    I think the cochrane review is more an indictment on our ability to successfully manage people in pain than it is on SMT specifically. Rather than taking joy in the lack of superiority of SMT for managing people with acute LBP, we should be frustrated that we don't have better solutions for people in pain.

    As you say in your blog "Unsurprisingly, there is no robustly evidence-based treatment for acute LBP apart from avoiding bed rest as much as possible." Based on the cochrane review…

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    1. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to jerry sprom

      Yes Jerry, but it does cost SOMETHING when it would be more cost-effective to provide education and not provide any hands-on treatment. Such a study has indeed been done before and published in the NEJM. http://www.nejm.org/doi/full/10.1056/NEJM199510053331406 In this study, cost for managing an episode of acute LBP was highest if the patient saw a chiropractor or an orthopaedic surgeon, and lowest if they saw a GP. The outcomes were the same regardless of who treated them.

      This review adds to the negative evidence that suggests we should be putting our efforts into helping people with an acute episode of LBP to self-manage rather than making up treatments that aren't really effective. That's certainly what we do in my hospital.

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    2. jerry sprom

      logged in via email @gmail.com

      In reply to Michael Vagg

      Thanks Michael,
      There is also this more recent study http://www.ncbi.nlm.nih.gov/pubmed/16226622 which makes reference to and comments on the study you cited. Their conclusion
      "Chiropractic care appeared relatively cost-effective for the treatment of chronic LBP. Chiropractic and medical care performed comparably for acute patients. Practice-based clinical outcomes were consistent with systematic reviews of spinal manipulation efficacy: manipulation-based therapy is at least as good as and, in…

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    3. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to jerry sprom

      It's a matter for philosophers whether feeling good about inferior outcomes is a net benefit or not. My feeling, as is the case for most health professionals, is that patient satisfaction is not a good measure of outcome if efficacy is not present. It's easy to get ppl to feel slightly better about their health predicaments, but that is not really good enough if you're not improving their measurable outcomes.

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  5. Edward John Fearn

    Edward John Fearn is a Friend of The Conversation.

    Hypnotherapist and Naturopath

    Thanks Michael

    This is quite disconcerting news in respect to the omega 3 findings.

    Firstly, while it is widely accepted that an intake of fish or omega 3 supplementation confer benefits to brain and visual system development in infants and some modest evidence that supports its use in rheumatoid arthritis(1), the question at hand however is does it have any value in reducing CVD mortality rates.

    Earlier papers demonstrated a clear link between fish consumption and decreased coronary heart…

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    1. Michael Vagg

      Clinical Senior Lecturer at Deakin University School of Medicine & Pain Specialist at Barwon Health

      In reply to Edward John Fearn

      Yes Edward, this finding reflects the process of science whereby several small studies with mixed positive and negative results when analysed together lead to more accurate findings that are closer to the overall truth. It is indeed 'widely accepted' but only on the basis of provisional evidence that now appears much less certain.

      As far as I can see, the only remaining use for high-dose omega 3 supplementation is for inflammatory arthritis for acute flareups. Possibly the Inuits and Japanese who eat lots of fish and have lower rates of CVD may have another reason besides fish intake for this finding.

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  6. Sue Ieraci

    Public hospital clinician

    One should not discount the value of a cup of tea and a chat. I use this therapeutic modality frequently in acute hospital practice. I haven't trialled it prior to implementing because it appears to have negligible adverse effects, the patient has to consent (they always do) and I don't charge for it.

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  7. Sue Ieraci

    Public hospital clinician

    The paper on acupuncture and pain relief illustrates the importance of critical review of research - whether it is mainstream medicine or "alternative".

    We live in a world with instant access to thousands of abstracts of papers, but barriers to the entire paper. (When journals were paper-only, those that accessed them could read the whole paper immediately after the abstract)>

    We need to be very wary about the difference between statistical and clinical significance, and also between test-based…

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