Early-life exposure to air pollution may contribute to the development of asthma in children.
Researchers used two groups of mice, one exposed to air pollution then allergens, and the other to allergens alone.
They found that the first group developed more asthma-like inflammation in their airways.
Tom Hennessy
Retired
When one is exposed to pollution , one manifests increased red blood cells. Asthma patients present with increased red blood cells. Increased red blood cells cause breathing problems . The drugs used to treat asthma are used to lower red blood cells , by lowering erythropoietin. Is? the asthma due TO the increased red blood cells?
"After an eight-week course of theophylline treatment, the mean (±SEM) serum erythropoietin levels were significantly reduced in both the renal-transplant recipients (from 60±14 units per liter at base line to 9±7 units after treatment; P<0.05) and the normal subjects (from 6.9±0.8 units per liter at base line to 4.7±0.5 units per liter after treatment"
Sue Ieraci
Public hospital clinician
Mr Hennessy - theophylline is a complex drug - now rarely used to treat asthma because of its mixed effect and the presence of other better therapies.
It action in reducing erythropoitin is thought to be through its ability to block adenosine. This is a very specific area related to the 10- 15% of patients who secrete increased erythropoitin post-renal transplant.
IN asthma, the action of theophylline is as a phosphodiesterase inhibitor, reversing bronchospasm.
None of this has anything to do with pollution, which does nothing to red cell mass unless one is significantly hypoxic.
Tom Hennessy
Retired
Theophylline is used specifically to lower red blood cells.
Asthma has higher red blood cells.
Deny it all you want.
It just makes your comments on transfusions and shock more understandable.
You simply have no idea what you are talking about and anything spoken by you MUST be taken with a grain of salt , with at least two other second opinions , because , like I said YOURS is worthless.
The NIH is presently funding for the replacement of theophylline.
Now why would they do that if it isn't being used ?
"None of this has anything to do with pollution, which does nothing to red cell mass"
Another stupid comment.
"Elevation of hemoglobin concentration through exposure to indoor air pollution"
Sue Ieraci
Public hospital clinician
Mr Hennessy - I suggest you look up contemporary therapy for asthma. The Asthma Foundation might be a good place to start.
Tom Hennessy
Retired
I'm pretty sure I told you what your suggestions are worth.
Tom Hennessy
Retired
"The goal of the asthma grant is to develop a selective blocker of the adenosine A2B receptor (A2BAR) that could replace theophylline,"
Theophylline is an iron binding drug.
Lung capacity is directly related to the amount of iron in the body , decreases as iron goes up .
"Study of Pulmonary Function Tests in Thalassemic Children"
They say asthma is not caused by high red blood cells but use drugs to reduce red blood cells , use bloodletting to treat terminal COPD patients who fail to respond to drugs , IE: theophylline.
Anyone want to buy a bridge ?
Tom Hennessy
Retired
Below is a report from someone being treated for iron excess.
"I don't know if it is a coincidence, but after several phlebs, my
asthma and allergy symptoms became better and have nearly cleared up. I was taking proventil, intal, vancenase, theophylline and beclovent daily. I no longer take theophylline, proventil and have cut back on the rest 90%. I have not had an attack, can smell food, do not have cotton mouth during the night for the first time in years and my wife says that I NO LONGER SNORE. It's probably a coincidence, but I like to think of it as a possible positive side affect."
Of course it is coincidence.
Sue Ieraci
Public hospital clinician
Mr Hennessy - who uses blood letting to treat terminal COPD patients? They should be reported to the regulatory authorities. Are they not up on non-invasive ventilation or BiPAP?
Sue Ieraci
Public hospital clinician
Editors: the study you describe allarently says that one group of rats had inflammation in their airways. Did they also have bronchospasm?
It seems that this bit of information does not justify the "air pollution leads to asthma" headline. Asthma is frequently familial, and part of an atopic tendency (a type of allergy). The most frequent precipitant for asthma attacks in predisposed people is ordinary respiratory viruses, followed by organic allergens.
Sue Ieraci
Public hospital clinician
(Oops - "apparently" in the first line, not "allarently" )