James Hungo Kimotho

Head of Department, Production, Kenya Medical Research Institute

2010 – 2016
Doctor of Philosophy (Molecular Medicine) – Jomo Kenya University of Agriculture and
Technology.
Thesis “Development of ELISA and lateral flow test kits for Human Immunodeficiency Virus guided by the prevailing consensus sequence of HIV Env gene in Kenya”

2007 – 2009 Master of Science (Molecular Medicine) – Jomo Kenya University of Agriculture and
Technology.

Major Career
Achievements
Thesis “Development of an ELISA kit for detection of HBsAg in plasma or serum based on polyclonal antibodies produced by KEMRI, Kenya.
1987–1991 University of Nairobi  Bachelor of Pharmacy
 Have developed major products
- Betaquine tablets, antimalarial
- Kemcom HIV 1 & 2 Immunochromatographic Rapid test kit
- Hepcell HBV Immunochromatographic Rapid test kit
- HBV ELISA Kit (Currently under development

JOURNALS PAPERS FOR THE LAST 5 YEARS

-James Kimotho, Zipporah Ng’ang’a, Edna Nyairo, Missiani Ochwoto, Nicholas
Nzioka, Francis Ogollah, Michael Kiptoo 2015 Development of
immunoassays for detection of Human Immunodeficiency Virus based on Consensus env gp41 Immunodominant Region Peptide from HIV-1 infections in Kenya Africa Journal
Pharmacology and Therapeutics.

-James Kimotho, Zipporah Ng’ang’a, Edna Nyairo, Missiani Ochwoto, Nicholas
Nzioka, Francis Ogolla, Michael Kiptoo
2015 Diversity within the Immunodominant Epitopes of Envelope gp41 from HIV-1 in Kenya and Its Effects on Performance of the HIV-1 Antibody-Based Detection Kits American Journal of Internal
Medicine.

- James Kimotho, Zipporah
Ng’ang’a, Edna Nyairo, Missiani Ochwoto, Nicholas Nzioka, Francis Ogolla, Michael Kiptoo
2015 Laboratory Evaluation of the Validity of the Current HIV Testing Algorithm in Kenya American Journal
of Internal Medicine.

Wasonga Caroline, Inoue S, Kimotho J, Morita K, Ongus J, Sang R, Musila L.
2015 Development-andEvaluation-of-an-inhouse-IgM-captureELISA-for-the-Detectionof-Chikungunya-and Japan Journal of Infection Diseases.

-Yoshito Fujii , Satoshi Kaneko , Samson Muuo Nzou, Matilu Mwau, Sammy
M. Njenga, Chihiro Tanigawa, James Kimotho, Anne Wanjiru Mwangi,
Ibrahim Kiche 2014 Serological Surveillance Development for Tropical Infectious Diseases Using Simultaneous
Microsphere-Based Multiplex Assays and Finite Mixture Models Journal of Neglected Tropical Diseases.

- Kwange SO, Budambula NL, Kiptoo MK, Okoth F, Ochwoto M, Oduor M, Kimotho JH. 2013 Hepatitis B virus subgenotype A1, occurrence of subgenotype D4, and S gene mutations among voluntary blood donors in Kenya. Virus Genes.

Ochwoto M, Chauhan R, Gopalakrishnan D, Chen CY, Ng'ang'a Z, Okoth F, Kioko
H, Kimotho J, Kaiguri P, Kramvis A 2013 Genotyping and molecular characterization of hepatitis B virus in liver disease patients in Kenya Infection, Genetics and Evolution.

-Missiani Ochwoto, FredricknOkoth, Henry Kioko, James Kimotho, Zipporah Ng’ang’a, Deepark K, Ranjit
Chauhan, and Anna Kramvis 2011 Hepatitis B Virus Basal Core Promoter and Precore Region Mutations among Liver Disease Patients at Kenyatta National Kenyatta Africa Journal of Health Science.

-Ochwoto M, Kimotho JH, Oyugi J, Okoth F, Kioko H, Mining S, Budambula NL,
Giles E, Andonov A, Songok E, Osiowy C 2016 Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya BMC infectious diseases.

-Caroline Wasonga; Shingo Inoue; Cecilia Rumberia; George Michuki; James Kimotho; Juliette R. Ongus; Rosemary Sang; Lillian Musila 2015 Chikungunya virus variants identified in human serum isolate from RT Comoros Island, 2005 Virus Genes.

-Ednah K. Nyairo, Zipporah Ng'ang'a, James Kimotho, Samoel A. Khamadi, Missiani Ochwoto, Joseph Mwangi3, and Raphael Lwembe 2016 Mutations in the “a” Determinant Region of Hepatitis B Virus Genotype A among Voluntary Kenyan Blood Donors Journal of Biology, Agriculture and Healthcare.

-Ayub K. Maina a, Joseph K.
Mbugua, Adriana Trajtman, Yoav Keynan, Robert W. Omange Annie Panikulam, Rachel N. Musoke, James Kimotho, Missiani Ochwoto , Daniel Kariuki, and Elijah M. Songok
2016 The Potential for DPPIV/CD26 usage as a surrogate marker for Antiretroviral Therapy Efficacy in HIV Infected populations Africa Journal Pharmacology and
Therapeutics.

Ochwoto, M., Muita, L., Talaam, K., Wanjala, C., Ogeto, F., Wachira, F., Kimotho, J., Ndegwa, L. 2017 Anti-bacterial efficacy of alcoholic hand rubs in the Kenyan market, 2015. Antimicrobial Resistance and Infection Control

Experience

  • –present
    Head of Department, Production , Kenya Medical Research Institute