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Marilize Le Roes-Hill

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Senior Researcher, Head of Biocatalysis and Technical Biology Research Group, Cape Peninsula University of Technology

Dr Marilize Le Roes-Hill graduated with a National Diploma in Food Service Management from the Cape Technikon (now Cape Peninsula University of Technology, CPUT) Hotel School, which sparked an interest in Food Microbiology. Subsequently, she completed a BSc in Microbiology and Biochemistry at the University of Cape Town (UCT), followed by a BSc (Hons) degree in Microbiology and a PhD in Molecular and Cell Biology (UCT). In 2006, she was appointed as a postdoctoral fellow within the Department of Chemical Engineering, UCT, under the supervision of Prof. Stephanie Burton. In 2009, Prof. Burton accepted the position of Director of Postgraduate studies at CPUT and her research group joined her at CPUT. Dr Le Roes-Hill completed her postdoctoral studies within the Biocatalysis and Technical Biology (BTB) Research Group in 2010 and in April 2011 took over the responsibilities of the research leader of the BTB Research Group. Dr Le Roes-Hill’s interests are in actinobacteria and their secondary metabolites (antibiotics and antioxidants), actinobacterial oxidative enzymes and their application in biocatalysis and biotransformations, as well as the bioremediation and beneficiation of industrial wastes. Dr Le Roes-Hill is the grantholder responsible for the LC-MS facility based at her research group, where they specialize in the analyses of small compounds, especially those derived from plants. Her personal interests in archaeology, ancient DNA studies and astrobiology lend a strong flavour of exploration for novel actinobacterial strains from biodiverse environments in the search for novel enzyme activities and bio-active compounds with potential industrial and pharmaceutical application, respectively.

Experience

  • 2014–present
    Senior Researcher, BTB Research group, Cape Peninsula University of Technology

Education

  • 2005 
    University of Cape Town, PhD Molecular and Cell Biology
  • 2001 
    University of Cape Town, BSc Honours Microbiology
  • 2000 
    University of Cape Town, BSc Microbiology and Biochemistry
  • 1997 
    Cape Technikon, ND Food Service Management

Publications

  • 2015
    Enzyme Microbial Technology , Prins A, Kleinsmidt L, Khan N, Kirby B, Kudanga T, Vollmer J, Pleiss J, Burton S, Le Roes-Hill M. (2015). The effect of mutations near the T1 copper site on the biochemical characteristics of the small laccase from Streptomyces coelicolor A3(2). Enzyme Microbial Technology 68: 23-32
  • 2015
    South African Journal of Science , Khan N, Le Roes-Hill M, Welz PJ, Grandin KA, Kudanga T, Van Dyk JS, Ohlhoff C, Van Zyl WH, Pletschke BI (2015). Fruit waste streams in South Africa and their potential role in developing a bio-economy. South African Journal of Science 111:1-11
  • 2015
    Frontiers in Microbiology, Kügler J, Le Roes-Hill M, Syldakt C, Hausmann R. (2015). Surfactants tailored by the class Actinobacteria. Frontiers in Microbiology 6:212; DOI=10.3389/fmicb.2015.00212
  • 2015
    Food Science and Technology International , Ngemakwe PHN, Le Roes-Hill M, Jideani V. (2015). Advances in gluten-free bread technology. Food Science and Technology International 21: 256-276
  • 2014
    Journal of Water Process Engineering , Welz PJ, Le Roes-Hill M. (2014). Biodegradation of organics and accumulation of metabolites in biological sand filters used for the treatment of synthetic winery wastewater. Journal of Water Process Engineering 3C: 155-163
  • 2014
    FEMS Microbial Ecology , Ramond J-B, Welz PJ, Le Roes-Hill M, Tuffin MI, Burton SG, Cowan DA (2014). Selection of Clostridium spp. in biological sand filters neutralizing synthetic acid mine drainage. FEMS Microbial Ecology 87: 678-690
  • 2014
    Journal of Antibiotics , Everest GJ, Le Roes-Hill M, Rohland J, Enslin S, Meyers PR. (2014). Amycolatopsis roodepoortensis sp. nov. and Amycolatopsis speibonae sp. nov., antibiotic-producing actinobacteria isolated from South African soils. Journal of Antibiotics 67: 813-818
  • 2014
    Journal of Environmental Management , Welz PJ, Palmer Z, Isaacs S, Kirby B, Le Roes-Hill, M (2014). Analysis of substrate degradation, metabolite formation and microbial community response in sand bioreactors: a comparative study. Journal of Environmental Management 145C: 147- 156
  • 2014
    Applied Microbiology and Biotechnology , Kudanga T, Le Roes-Hill M (2014). Laccase applications in biofuels production: current status and future. Applied Microbiology and Biotechnology 98: 6525-6542
  • 2014
    Biotechnology and Bioprocess Engineering , Welz PJ, Ramond J-B, Cowan DA, Burton SG, Le Roes-Hill M (2014). Minor differences in sand physicochemistry lead to major differences in bacterial community structure and function after exposure to synthetic acid mine drainage. Biotechnology and Bioprocess Engineering 19: 211-220
  • 2014
    Journal of Applied Microbiology , Musengi A, Khan N, Le Roes-Hill M, Pletschke BI, Burton SG (2014). Increasing the scale of peroxidase production by Streptomyces sp. strain BSII#1. Journal of Applied Microbiology 116: 554-562
  • 2013
    Wynboer Technical Yearbook, Welz, P.J., Haldenwang, R., Ramond, J-B. & Le Roes-Hill, M. (2013). Winery wastewater treatment – keeping it cheap and simple. Wynboer Technical Yearbook 2013, pp122- 124
  • 2013
    Antonie van Leeuwenhoek , Everest GJ, Le Roes-Hill M, Omorogie C, Cheung S-K, Cook AE, Goodwin CM, Meyers PR (2013). Amycolatopsis umgeniensis sp. nov., isolated from soil from the banks of the Umgeni River in South Africa. Antonie van Leeuwenhoek 103: 673-681
  • 2012
    Journal of Molecular Catalysis B: Enzymatic , Adelakun OE, Kudanga T, Parker A, Le Roes-Hill M, Burton S (2012). Biocatalytic modification of ferulic acid by laccase from Trametes pubescens. Journal of Molecular Catalysis B: Enzymatic 74: 29-35
  • 2012
    Process Biochemistry , Adelakun OE, Kudanga T, Green IR, Le Roes-Hill M, Burton SG (2012). Enzymatic modification of 2,6-dimethoxyphenol for the improvement of antioxidant capacity. Process Biochemistry 47: 1926-1932
  • 2011
    Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats , Kirby BM, Le Roes-Hill M, Cary SC, Burton SG, Tuffin IM, Cowan DA (2011). Actinobacterial diversity associated with Antarctic Dry Valley mineral soils. In: Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats (ed F.J. de Bruijn), John Wiley & Sons, Inc., Hoboken, NJ, USA. Doi:10.1002/9781118010549.ch13.
  • 2011
    Applied Biochemistry and Biotechnology , Le Roes-Hill M, Khan N, Burton SG (2011). Actinobacterial peroxidases: An unexplored resource for biocatalysis. Applied Biochemistry and Biotechnology 164: 681- 713
  • 2011
    Systematic and Applied Microbiology , Everest GJ, Cook AE, Le Roes-Hill M, Meyers PR (2011). Nocardia rhamnosiphila sp. nov., isolated from a compost heap. Systematic and Applied Microbiology 34: 508- 512
  • 2011
    Antonie van Leeuwenhoek , Le Roes-Hill M, Rohland J, Burton SG (2011). Actinobacteria isolated from termite guts as a source of novel oxidative enzymes. Antonie van Leeuwenhoek 100: 589-605
  • 2009
    Environmental Microbiology , Babalola OO, Kirby BM, Le Roes-Hill M, Cook AE, Cary SC, Burton SG, Cowan DA (2009). Phylogenetic analysis of actinobacterial populations associated with Antarctic Dry Valley mineral soils. Environmental Microbiology 11: 566 – 576
  • 2009
    Trends in Biotechnology , Le Roes-Hill M, Goodwin CM, Burton SG (2009). Review paper. Phenoxazinone synthase: What’s in a name? Trends in Biotechnology 27: 248 – 258
  • 2009
    International Journal of Systematic and Evolutionary Microbiology, Le Roes-Hill M, Meyers PR (2009). Streptomyces polyantibioticus sp. nov., isolated from the banks of a river. International Journal of Systematic and Evolutionary Microbiology 59: 1302 – 1309
  • 2009
    International Journal of Systematic and Evolutionary Microbiology , Le Roes-Hill M, Rohland J, Meyers PR, Cowan DA, Burton SG (2009). Streptomyces hypolithicus sp. nov., isolated from an Antarctic hypolith community. International Journal of Systematic and Evolutionary Microbiology 59: 2033 – 2036
  • 2008
    Multi-step enzyme catalysis: Biotransformations and Chemoenzymatic synthesis., Burton SG, Le Roes-Hill M (2008). Chapter 3: Oxidizing Enzymes in multi-step biotransformation processes in Multi-step enzyme catalysis: Biotransformations and Chemoenzymatic synthesis. Edited by E. Garcia-Junceda, WILEY-VCH, Germany.
  • 2008
    Systematic and Applied Microbiology, Le Roes M, Goodwin CM, Meyers PR (2008). Gordonia lacunae sp. nov., isolated from an estuary. Systematic and Applied Microbiology 31: 17 – 23
  • 2008
    Antonie van Leeuwenhoek , Le Roes M, Meyers PR (2008). Nonomuraea candida sp. nov., a new species from South African soil. Antonie van Leeuwenhoek 93, 133-139
  • 2007
    International Journal of Systematic and Evolutionary Microbiology , Le Roes M, Meyers PR (2007). Actinomadura rudentiformis sp. nov., isolated from soil. International Journal of Systematic and Evolutionary Microbiology 57: 45 – 50
  • 2007
    Journal of Applied Microbiology , Wood SA, Kirby BM, Goodwin CM, Le Roes M, Meyers PR (2007). PCR screening reveals unexpected antibiotic biosynthetic potential in Amycolatopsis sp. strain UM16. Journal of Applied Microbiology 102: 245 – 253
  • 2006
    Antonie van Leeuwenhoek, Le Roes M, Meyers PR (2006). Nocardia gamkensis sp. nov. Antonie van Leeuwenhoek 90: 291 – 298
  • 2006
    International Journal of Systematic and Evolutionary Microbiology, Kirby BM, Le Roes M, Meyers PR (2006). Kribbella karoonensis sp. nov. and Kribbella swartbergensis sp. nov., isolated from soil from the Western Cape, South Africa. International Journal of Systematic and Evolutionary Microbiology 56: 1109 – 1115
  • 2005
    International Journal of Systematic and Evolutionary Microbiology, Cook AE, Le Roes M, Meyers PR (2005). Actinomadura napierensis sp. nov., isolated from soil in South Africa. International Journal of Systematic and Evolutionary Microbiology 55: 703 – 706
  • 2005
    Systematic and Applied Microbiology , Le Roes M, Meyers PR (2005). Streptomyces pharetrae sp. nov., isolated from soil from the semi-arid Karoo region. Systematic and Applied Microbiology 28: 488 – 493

Grants and Contracts

  • 2015
    Project K5/2489 National survey on the water and wastewater management practices in the textile industry
    Role:
    Principal investigator
    Funding Source:
    Water Research Commission of South Africa
  • 2014
    Actinobacterial diversity associated with rooibos plants
    Role:
    Co-investigator
    Funding Source:
    National Research Foundation of South Africa
  • 2014
    Mining actinobacterial diversity for novel bio-active compounds
    Role:
    Principal investigator
    Funding Source:
    National Research Foundation of South Africa
  • 2013
    Project K5/2225 Integrated bioremediation and beneficiation of bio-based waste streams
    Role:
    Co-investigator
    Funding Source:
    Water Research Commission of South Africa
  • 2013
    Enzyme-mediated functionalisation of biomaterials by antioxidant compounds found in tea extracts
    Role:
    Principal investigator
    Funding Source:
    Cape Peninsula University of Technology
  • 2012
    Biomimetic approach for the production of metal nanoparticles
    Role:
    Principal investigator
    Funding Source:
    Cape Peninsula University of Technology
  • 2011
    SA-Germany bilateral (laccases and other multi-copper oxidases)
    Role:
    Principal investigator
    Funding Source:
    National Research Foundation of South Africa
  • 2011
    National Equipment program
    Role:
    Grant-holder
    Funding Source:
    National Research Foundation of South Africa
  • 2009
    Project K5/2009.1//3 Tunable Immobilised Lignocellulosic Enzyme (TILE) system
    Role:
    Co-investigator
    Funding Source:
    Water Research Commission of South Africa

Professional Memberships

  • American Association for the Advancement of Science (AAAS)
  • Bergey’s International Society for Microbial Systematics (BISMiS)
  • Botanical Society of South Africa
  • Royal Society of South Africa (RSSA)
  • South African Society of Microbiology (SASM)