Dr Ruben Cloete successfully completed a PhD in Bioinformatics at the South African National Bioinformatics Institute (SANBI), University of the Western Cape (UWC) in 2013, under supervision of Professor Alan Christoffels. His PhD focused on the identification of novel drug targets in the genome of Mycobacterium tuberculosis and the prediction of the three dimensional structures for protein-drug targets. He also used molecular docking techniques to identify potential inhibitors to treat drug resistant forms of Tuberculosis. During his PhD studies he spent a month in the laboratory of Professor Marc A. Marti-Renom (Centro de Investigación Príncipe Felipe, Valencia, Spain)
and received comprehensive training in comparative protein structure modeling and molecular docking. During his post-doctoral fellowship at SANBI, UWC he was introduced to, and started implementing methods of molecular dynamic simulation. He spent a further two months in the laboratory of Professor Chandra Verma, at the (A-star Bioinformatics Institute, Biopolis, Singapore) and mastered methods in molecular modelling, simulation studies of protein-ligand and protein-protein complexes, as well as methods in drug discovery and design.