The core research activities in my laboratory are in-depth investigations of viral diseases, their pathogenesis, treatment and prevention and virus-host interactions, including the role of soluble mediators and cell subsets in virus-induced disease.
My major focus are:
- To define the cellular and molecular processes by which arthrogenic viruses (chikungunya and Ross River viruses) cause and/or exacerbate rheumatic disease
- To define the immune response to dengue virus and characterize the mechanisms of disease using a mouse model
- To define the mechanisms employed by alphaviruses to evade the early interferon response within the infected host
- To analyse the molecular determinants of alphavirus virulence and fitness during transition from mosquito vectors to the vertebrate host
- To define the mechanisms that contribute to human airway disease and asthma associated with human metapneumovirus virus, respiratory syncytial virus and rhinovirus infections, and to define the role that the immune response may have on disease pathogenesis
- To develop novel antivirals and vaccines against chikungunya and dengue viruses.