Malaria

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Mefloquine’s chemical structure is based on one of the first malaria drugs, quinine, that comes from the bark of South America’s Cinchona tree. Cinchona seedlings being packaged for shipment to make quinine, 1943/NLM

Weekly Dose: mefloquine, an antimalarial drug made to win wars

Mefloquine was one of around 250,000 chemical compounds tested for malaria-killing activity in the 1960s by the United States military who needed to protect troops from malaria in the tropics.
A father reads to his son while sitting under a mosquito net. Mosquitoes have undergone evolutionary changes due to long-lasting insecticide-treated nets. Georgina Goodwin and Vestergaard Frandsen

Why evolution must be at the centre of fighting parasitic infections

Although there have been global efforts to eliminate parasites, some parasites and vectors will have survived attack because they have evolved resistance.
Municipal workers wait before spraying insecticide to prevent the spread of Aedes aegypti mosquito at Sambodrome in Rio de Janeiro, Brazil, January 26, 2016. Pilar Olivares/Reuters

Explainer: where did Zika virus come from and why is it a problem in Brazil?

Zika was discovered almost 70 years ago, but wasn't associated with outbreaks until 2007. So how did this formerly obscure virus wind up causing so much trouble in Brazil?
Relapsing infections are critical for sustained malaria transmission in the Asia-Pacific. Mayeta Clark/Walter and Eliza Hall Institute

To eliminate malaria in the Asia-Pacific we need to target recurrent infections

A large number of children with malaria in the Asia-Pacific have relapses of the disease, not new infections. Malaria-programs must target these latent infections to completely eliminate the disease.
Anopheles Gambiae, one of three mosquitoes found in Africa that transmit malaria. shutterstock

Seven things worth knowing about mosquitoes

The irritating buzz that rings in your ear in the dead of the night comes from an insect barely traceable with your naked eye. Here are a few facts worth knowing about the mosquito.

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