Bacteria resistant to antibiotics are reaching epidemic proportions around the world, particularly in developing countries. In Australia, we’re also seeing increasing numbers of serious infections which are very difficult or impossible to treat. This is because the bacteria causing these infections are resistant to most – and sometimes all – antibiotics. These strains of bacteria are known as superbugs.
Superbugs are able to resist the effects of the antibiotics we direct against them. They have effectively put on bullet-proof vests against our “magic bullets” (antibiotics) that cured people with serious infections. They do this by destroying the drug or altering the “goal posts”, by changing the receptors where these drugs need to bind and act.
When serious infections can’t be treated with common antibiotics, the risk of complications and death increases exponentially. People with antibiotic-resistant E. coli or golden staph (MRSA) bloodstream infections, for example, not only have a greater likelihood of death but the survivors spend, on average, an extra five days in hospital. This also increases health-care costs.
As superbugs develop resistant to more and more types of antibiotics, we may face a future without effective antibiotics. The only option, then, would be to revert to 1930s-style medical care treat serious infection: surgically remove the infection, which may result in amputation.
There is, however, a lot we can do as individuals and as a community, through our governments, to improve the situation and reduce the risk of being infected with a superbug.
Reducing individual risk
Here are five ways you can reduce your risk of contracting superbug:
Maintain good personal care and hygiene. Regularly washing your hands with soap or alcohol gel is one of the most effective ways to protect yourself and those around you from infection.
Make sure your health is as good as it should be, as this will optimise the body’s response and immunity against bugs. This means making sure your immunisations are up-to-date and ensuring you seek timely medical care when something goes wrong.
Limit the antibiotics you receive. More than half of antibiotics used in people are to treat viral infections, for which antibiotics do not work. Whenever you see your doctor and are prescribed antibiotics, ask if you really need to take them.
Be vigilant when travelling. In developing countries such as India, many people acquire superbugs through water and food. Uncooked meats contain large numbers of bacteria and fruits and vegetables are frequently cross contaminated. Only drink boiled water or water from a reputable supplier and eat hot foods, as heat kills these bacteria. With fruits, make sure the skins have been cleaned and you peel the fruit yourself with clean hands.
Avoid medical tourism. Health-care facilities in developing countries have extremely high rates of superbugs compared with Australia.

Governments also need to do much more to reduce the threat of superbugs in the community.
Use in animals
Worldwide, about 80% of all antibiotics are used in food animals. High volumes are added routinely to animal feed or in water to prevent disease and, at times, to promote growth. But these antibiotics provide no or marginal benefit. The use of antibiotics as growth promoters should be banned as soon as possible.
Currently, some of the most important classes of antibiotics are fluoroquinolones and third-generation cephalosporins. But around the world, large volumes are used in food animals. If these classes of last-resort drugs are ineffective because of resistance, there may be no therapy for life threatening infections.
Antibiotics classed as “critically important” by the World Health Organization should be reserved for use in people.
Renew our focus on safe water
In the developing world, large numbers of superbugs are acquired and spread via water. In New Delhi, multi-resistant bacteria such as New Delhi metallo-beta-lactamase 1 (NDM-1) can even be found in the chlorinated water supply.
The availability of clean, safe water for everyone in the world would make a huge difference to our superbug problem. It will stop their spread to large numbers of people, as well as to and from food animals.
Hospitals
Back home, the most effective way to decrease the spread of superbugs in hospitals is to enforce strict hand hygiene policies. We should encourage patients to be more assertive and say to their doctors or nurses, “I’d like to see you clean your hands before you touch me”. Portable small containers of alcohol hand rub are a good alternative to soap and water.
Hospital design can also decrease the spread of superbugs. Providing each patient with a toilet for their own, for example, reduces the need for multiple patients to share bathroom facilities, and, inevitably, superbugs.
Research, development and control
Governments must invest in ongoing research to find new classes of antibiotics, improved vaccines and finding better way to stop the spread of superbugs.
We also need better surveillance of antibiotic-resistant bacteria in people, foods and food animals.
And finally, the international community must implement better controls on antibiotic usage. All antibiotics (human and agriculture) should be on prescription and usage patterns captured.
Superbugs are with us and increasing worldwide. We as individuals and as a community can however do many things to lower the risk of superbugs.
Sue Ieraci
Public hospital clinician
In the context of this article, what does the author think of this news story:
"An inquest into the four-month-old's death was adjourned until April to wait for the results of a pilot program for dealing with children showing signs of sepsis - a potentially lethal response to infection.
The scheme would later be introduced in NSW hospitals.
Draft guidelines include the use of antibiotics within the first hour for any child with key symptoms, such as a fever above 38.5C."
We know that…
Read moreCraig Morton
Biomedical Research Scientist
Interesting Sue. I'm not a clinician, but I'd have thought that there should be good statistics on things like allergy, side-effects etc. that could be stacked against the prevelance of bacterial meningitis in the context of particular symptoms. Surely there are evidence-based guidelines that weigh the cost-benefit of an immediate antibiotic dose in the circumstances you've described?
Sue Ieraci
Public hospital clinician
The problem, Craig, is that meningitis is a very low-prevalence condition with a very high impact.
The other issue, which is why some cases of meningitis in infants are missed in the early stages, is that the early signs are very general - especially in babies. The ones with obvious symptoms and signs are not the ones that are missed.
The evidence-base is very difficult to build here, because the easy to collect symptoms and signs (the "classic" presentation) isn't so hard to identify - it…
Read moreLuke Weston
Physicist / electronic engineer
"Whenever you see your doctor and are prescribed antibiotics, ask if you really need to take them."
Furthermore, patients should not ask for or pressure the practitioner for antibiotics if they are not indicated.
Bruce Tabor
Research Scientist at CSIRO
While I agree with the article I think the title is wrong. Following the prescription described, the best we can do is slow the spread of superbugs and reduce our personal risk. We beat smallpox. In contrast, we're going to have to learn to live with superbugs.
Is The Conversation using tabloid style headlines in order to increase readership?
Michael Hansen
Michael Hansen is a Friend of The Conversation.
Retired, economist
What scope is there for us to follow the Russians and use bacteriophages rather than antibiotics?
John Holmes
Agronomist - semi retired consultant
Just substitute the pesticide for antibiotic and that is what is happening in Agriculture etc and in public health with disease vectors. It's all the same ecological dance. Compared with Nature, Man has a disadvantage; we need to get our chemicals approved first.
The development of resistance in weeds to a wide range of herbicides has with some products been very rapid. As few as 4 applications to select a managerial significant resistant population. I have wondered just how long we would…
Read moreTom Hennessy
Retired
The reason our antibiotics are not working any longer is because we allow the government to add the metal iron to all our foods.
"Growth in iron-supplemented medium also stimulated surface adhesion, thus suggesting that increased intracellular iron concentrations might act as an environmental signal for biofilm formation in A. baumannii SMAL."
Sue Ieraci
Public hospital clinician
Oops - Tom - you forgot this bit:
"We have studied how growth conditions and exposure of A. baumannii SMAL to subinhibitory concentrations of imipenem affects its ability to form biofilm, a cellular process with important consequences on sensitivity to antimicrobial agents and on microbial persistence in the human host." and
"Conclusions
Our results indicate that exposure to subinhibitory concentrations of imipenem can stimulate biofilm formation and induce iron uptake in a pathogenic strain of A. baumannii, with potential implications on antibiotic susceptibility and ability to persist in the human host."
Your citation is a study of how the antibiotic Imipenem was shown to reduce the ability of the organism Acinetobacter baumannii to form a biofilm, which is the proposed mechanism for its resistance.
Now I'm going off to eat an non-iron-boosted lunch.
Tom Hennessy
Retired
Actually , it shows how increased iron stimulates bacteria biofilm developement. Whether imipenem , a drug , works is neither here nor there , because , as shown , it works on the basis of ? iron.
Tom Hennessy
Retired
"A full blown proliferation of the mycobacteria population can be activated as soon as the levels of free iron are elevated within the host tissues"
Tom Hennessy
Retired
"Now I'm going off to eat an non-iron-boosted lunch"
It would have to be vegetarian.
"We found that healthy individuals absorbed about 16x more iron from the
hamburger meal than the wheat muffin meal"
Sue Ieraci
Public hospital clinician
"Whether imipenem , a drug , works is neither here nor there , because , as shown , it works on the basis of ? iron."
Nope.
This is the formula for Imipenen: C12H17N3O4S·H2O 317.36
Its anti-bacterial effect is through interfering with bacterial ability to form cell walls.
Sue Ieraci
Public hospital clinician
Neither hamburger nor wheat muffin.