Some of the major events in US-Iran relations highlight the differences between the nations' views, but others presented real opportunities for reconciliation.
Since President Donald Trump took office, Iranians have held a more unfavorable view of the US.
Although neither side apparently wants conflict, tensions remain over the presence of US troops in Iraq and Iran's decision to walk away from part of the 2015 nuclear deal.
Iran has withdrawn from key elements of the 2015 nuclear deal. The UK should respond with caution – and flexibility.
Given the perils of direct confrontation with the US, the most likely recourse for Iran may be to mobilise its proxy militias to attack American assets in Iraq.
It's very dangerous to assume that Iran will not escalate the crisis further, much less that the US could limit any violence that might ensue.
President Trump's Iran policy took a dramatic turn when the US killed Iran's top military commander in a drone strike. To avoid war, one foreign policy scholar says Trump has to reverse his stance.
How policy has shifted back and forth since 1945 over the fine line between nuclear energy and nuclear weapons.
Iran's goal is to sow discord and inflict pain on energy markets, while avoiding crossing a threshold that prompts retaliation from the US. This is a fine line to walk at the best of times.
A fifth of the world's oil travels through the narrow waterway.
Iranian President Hassan Rouhani staked his political fortunes on bringing Iran out of isolation. Now, it appears he's losing control to hard-liners in Iran.
Iran has announced it will breach the limits on uranium enrichment agreed under the 2015 nuclear deal, after the US turned its back on the agreement. What does that mean for Iran's nuclear program?
The US has imposed new sanctions against Iran's top leaders, but its foreign policy has no clear focus.
A showdown with Iran over some oil tanker attacks in the Persian Gulf could push the US into its next Mideast war, writes a scholar of military aggression.
Both Iran and the US say they are not seeking a war, but it could happen by default.
Reformers have tried to modernise Iran for decades but have failed mainly due to the country's powerful theocracy. And then there are those who want to overthrow the regime altogether.
Iran has threatened to shut down this narrow seaway. Here's why that could be a big deal.
Recent protests in Tehran's Grand Bazaar are part of a long reform movement, not a new revolution.
Seven world leaders with axes to grind are preparing to sit round one table. Sparks will fly.
The recent parliamentary election in Iraqi may have been the most transformative of the post-Saddam era, a pollster from Baghdad and an American academic explain.