Aducanumab (Aduhelm) was approved in the U.S., but there is no convincing evidence the drug will help Alzheimer’s patients.
FDA approval of aducanumab (Aduhelm) was contentious. Its submission to Health Canada for approval highlights concerns about evidence, independence and transparency in Canada’s drug approval process.
There are different types of memory and not all of them are related to Alzheimer’s disease.
Alzheimer’s disease is often associated with a decline in episodic memory. Patients will complain that they can’t remember events they’ve experienced, conversations they’ve had, things they’ve done.
Alzheimer’s, like many diseases, has a genetic component.
Tek Images/Science Photo Library via Getty Images
Using a technique called admixture mapping, researchers can leverage the diversity of people with mixed ancestry to look for hard-to-find genetic risk factors for diseases like Alzheimer’s disease.
Ubiquitin tags in cells serve different functions depending on stress conditions.
Insight on how a unique protein plays a role in cellular stress responses may provide more clues on how to treat diseases like ALS and Alzheimer’s.
Clinical trials of the drug have shown mixed results.
Alzheimer’s disease is characterized by progressive memory loss, spatial disorientation and many other cognitive and behavioural disorders that ultimately lead to a state of total dependence.
The new drug is based on the idea that a build-up of amyloid in the brain leads to the disease. But that hypothesis has been under scrutiny lately.
More research is needed to prove the drug slows cognitive decline.
Atthapon Raksthaput/ Shutterstock
The first drug targeting Alzheimer’s disease has been approved in 20 years – but its approval isn’t based on substantial evidence.
Do the benefits of approving a drug before confirming it works outweigh the potential costs?
monkeybusinessimages/iStock via Getty Images Plus
The FDA approved Alzheimer’s disease drug aducanumab despite minimal evidence of its efficacy. Whether this decision ultimately hurts or helps patients depends on data researchers don’t yet have.
Isolation and segregation create and reinforce another kind of barrier to those with dementia: stigma.
‘Dementia friendly’ communities seek to support people with memory loss, recognize them as equals, celebrate their contributions and enable them to live with purpose in welcoming communities.
The colors in this microscope photo of a fruit fly brain show different types of neurons and the cells that surround them in the brain.
Sarah DeGenova Ackerman
Adaptable neurons are tied to learning and memory but also to neurological disorders. By studying fruit flies, researchers found a mechanism that controls neuroplasticity.
Olivia Coleman and Anthony Hopkins in The Father (2020)
A neuroscientist and a clinician watched two new films about dementia. They recognised what they saw.
The equivalent of one bacon rasher was associated with 44% increased dementia risk.
If so, it’s just one lifestyle risk among many others.
Nanodiamonds aren’t just cellular bling: they could be used to better understand the development of cancer in our cells.
Currently, the only approved drugs for Alzheimer’s merely alleviate some of the symptoms — partially and temporarily — but do not stop the disease from progressing.
It was first officially described 115 years ago, but we still do not have a cure for Alzheimer’s disease. The human brain is extremely complex, and Alzheimer’s is its most complex disease.
The final piece in the dementia puzzle is at the door.
A new study says African Americans with dementia carry a higher risk for COVID-19 than whites with dementia.
Because dementia patients are more likely to acquire COVID-19, and because so many live in close-quarter facilities – like nursing homes – it’s critical to vaccinate them as quickly as possible.
Amyloid plaques are one cause of Alzheimer’s disease.
The researchers developed a molecule which works to stop toxic proteins from building up in the brain.
Being overweight or obese negatively affects brain health.
Atthapon Raksthaput/ Shutterstock
In this new study, people who were overweight had fewer brain cells and lower levels of blood flow compared to people of a normal weight.
The loss of neurons leads to degeneration.
Knowing what cells are more vulnerable could some day help researchers know why these cells are more vulnerable than others.
Air pollution exposure during mid to early life may be more important to developing Alzheimer’s disease than doctors realized.
Cecilie Arcurs via Getty Images
The tiny air pollutants known as PM2.5, emitted by vehicles, factories and power plants, aren’t just a hazard for lungs. A study finds more brain shrinkage in older women exposed to pollution.