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The use of naloxone administered by nasal spray can be a lifesaving drug with minimal side effects. TG23/iStock via Getty Images Plus

FDA approval of over-the-counter Narcan is an important step in the effort to combat the US opioid crisis

The Food and Drug Administration’s approval of Narcan will make the lifesaving drug more widely available, especially to those who might be likely to witness or respond to opioid overdoses.
Although xylazine is not an opioid, naloxone can reverse the effects of the fentanyl and heroin it is often mixed with. AP Photo/Jae C. Hong

What is xylazine? A medical toxicologist explains how it increases overdose risk, and why Narcan can still save a life

Xylazine, or tranq, is increasingly being mixed with drugs like fentanyl or heroin and can be difficult to detect. Most people who use drugs are unable to tell if they have been exposed to it.
Naloxone, available as a nasal spray called Narcan or in injectable form, resuscitates 100% of people who overdose if administered quickly. AP Photo/Patrick Semansky

This overdose-reversal medicine could reduce opioid deaths – so why don’t more people carry it?

Opioid overdoses killed 47,000 Americans in 2017 — more than gun violence. Many fewer would have died if they’d been treated with the life-saving drug naloxone, also called Narcan.
U.S. Surgeon General Dr. Jerome Adams demonstrates the proper procedure for administering a nasal injection of naloxone on reporter Jennifer Lott, left, during a visit to the University of Mississippi Medical Center in Jackson, Miss., May 17, 2018. AP Photo/Rogelio V. Solis

Naloxone remains controversial to some, but here’s why it shouldn’t be

One study argues that naloxone increases opioid use because it protects against death from overdose. But a closer analysis shows Narcan is the number one public health tool to fight the overdose epidemic.
Paul Wright, in treatment for opioid addiction in June 2017 at the Neil Kennedy Recovery Clinic in Youngstown Ohio, shows a photo of himself from 2015, when he almost died from an overdose. AP Photo/David Dermer

How Big Pharma is hindering treatment of the opioid addiction epidemic

The number of people dying from opioid overdose continues to rise, in part because of cheap street drugs. Yet the price of a drug used to treat addiction is out of reach for many.
Opioid addicts now being armed with overdose antidote. Gretchen Ertl/Reuters

Explainer: naloxone, the antidote to opioid overdose

Many first responders’ – even some university police officers – are carrying a new tool in their first-aid kits. It’s naloxone, the opioid overdose antidote drug, and today it’s more widely available than…

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