The South African Centre for Epidemiological Modelling & Analysis (SACEMA) is a national research centre established under the Centres of Excellence programme of the Department of Science and Technology and the National Research Foundation, and based at Stellenbosch University. Our core mission is to improve health in South Africa and across the continent through model-based analysis. Trained in mathematics, biology, physics, economics, statistics, and epidemiology, our researchers bridge disciplines to understand disease dynamics and improve real-world outcomes. Since it was founded in 2006, SACEMA has developed a robust and impactful research program in quantitative infectious disease epidemiology. Our current research falls under two broad themes: at the scale of individual patients, we work on biomarkers, drug targets, and diagnostics, and at the population scale, we focus on transmission, dynamics, and interventions. SACEMA also builds local and international capacity in epidemiological modelling and analysis by training postgraduate researchers to work across disciplines and across borders, and through workshops and short courses that build skills across sectors.