In general, my research interests concentrate on the molecular mechanisms involved in chronic systemic inflammation and subsequent accelerated atherosclerosis associated with type 2 diabetes and obesity. Specifically, I am interested in the role of hyperglycaemia and advanced glycated end-products (AGEs), and their respective receptor (AGER), in the development of atherosclerotic lesions. I am also interested in the way in which PPAR gamma ligands (both synthetic and natural) and exercise and diet can modulate intracellular signalling cascades, alter gene expression and ultimately interfere with the atherosclerotic and inflammatory pathways that are central to the pathological complications associated type 2 diabetes. The overall outcome of this research is to elucidate the beneficial molecular effects that drug intervention, alteration of diet and increased physical activity can have on insulin resistance and diabetes-associated atherosclerosis. Iis envisaged that the knowledge gained during this research will ultimately be translated to create more effective preventative, treatment and management schemes for obesity and diabetes.