I am interested in the neural circuits underlying the regulation of cognition and emotion of relevance to our understanding of a variety of neuropsychiatric and neurodegenerative disorders. In particular my lab focusses on the prefrontal control of subcortical circuitry involved in processing positive and negative emotions. The overall aim is to fractionate the neurocognitive circuits that underlie the regulation of emotion and to relate them to the distinct symptoms of emotion dysregulation present, not only in anxiety and depression, but also schizophrenia, autism and neurodegenerative disorders, such as Parkinson's disease. We combine a range of different experimental techniques and approaches including neuropsychopharmacology, remote measurement of cardiovascular activity, in vivo microdialysis, microPET and MRI. The lab is also interested in the relationship of activity in these neurocognitive circuits with individual differences in behavioural phenotypes, e.g. trait anxiety, and genotypes, during development as well as in adulthood.