My research can be described as translational physiology and examines the effect of atrophic stimuli upon muscle size both in vitro and in vivo, with particular focus on the regulation of cell size and the role of myostatin signalling in this process. In vitro, I use the C2C12 mouse myoblast line, perturbed with atrophic or hypertrophic stimuli, before examining changes in cell size by microscopy and alterations in cellular signalling pathways by Western blot. In vivo healthy humans are exposed to stimuli such as disuse, hypoxia or resistance training, with blood and muscle tissue collected for analysis. By understanding the basic science of how muscle is gained and lost when homeostasis is challenged, I hope to uncover the mechanism underlying atrophy of muscle during disease and aging, and ultimately prevent them.
I also have a secondary research focus on the integration of modern digital tools (tablets, wearables and smartphones) into physiology teaching and research.