During the last century, the indigenous South American Lowlands have been colonized by steamboats, railways, trucks, chainsaws, fire-weapons and electric generators introduced by missionaries, extractive industries, armies, development projects, and NGOs. However, anthropological and historical research has largely neglected this mechanical colonisation of indigenous life; in particular, there are almost no studies that analyse the current tide of motorcycles that during the last few decades altered dramatically the interethnic landscape, and its social, economic and environmental repercussions which are significantly reshaping current indigenous reality. The goal of my research project is to analyze the effects of motorcycle dissemination among the indigenous peoples of Bolivian Amazonia, and to achieve practical impact regarding public policies on road safety and prevention of accidents in marginal contexts.