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Havovi Chichger

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Senior Lecturer, Anglia Ruskin University

Research interests include:
• Physiological roles of bitter and sweet taste receptors
• Renal and small intestinal glucose transport across the epithelium (diabetes, metabolic syndrome)
• Mechanisms regulated by artificial sweeteners and sweet taste receptors (diabetes, pulmonary diseases)
• Endosomal trafficking in the vasculature (pulmonary diseases)
• Protein phosphatase (PTP and SHP2) signalling (pulmonary diseases)
• Protein kinases (PKC and MAPK) signalling (diabetes, pulmonary diseases)
• Novel mechanisms regulating microvascular complications (diabetes, pulmonary diseases)
• Molecular mechanisms which link the gut microbiota and gastric permeability

Experience

  • –present
    Senior Lecturer, Anglia Ruskin University
  • 2011–2015
    Postdoctoral research fellow, Brown University

Education

  • 2011 
    University College London, PhD in Physiology
  • 2004 
    King's College London, BSc Biochemistry

Publications

  • 2017
    Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2016
    Select Rab GTPases regulate the pulmonary endothelium via endosomal trafficking of VE-cadherin. , American Journal of Respiratory Cell and Molecular Biology.
  • 2016
    Differential regulation of renal glucose transporters: Implications for diabetic nephropathy. , Experimental Physiology.
  • 2015
    p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. , FASEB Journal
  • 2015
    SHP2 and FAK protein interactions regulate pulmonary endothelium barrier function. , American Journal of Respiratory Cell and Molecular Biology.
  • 2015
    PKC δ and βII Regulate Angiotensin II Mediated Fibrosis through p38: A Mechanism of RV Fibrosis in Pulmonary Hypertension. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2015
    Vasculogenesis in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2013
    Luminal proteolytic activation of the collecting duct epithelial sodium channel (ENaC) and its possible role in renal sodium reabsorption in vivo. , Nephrology Dialysis Transplantation.
  • 2012
    Protection against LPS-induced pulmonary edema through the attenuation of PTP1B oxidation. , American Journal of Respiratory Cell and Molecular Biology.
  • 2012
    Genetic Disruption of PKCδ Reduces Endotoxin-Induced Lung Injury. , American Journal of Physiology-Lung Cellular and Molecular Physiology.
  • 2012
    Investigation of Protein kinase C Isoforms in the Formation of Focal Adhesion Complexes by ECIS. , Cancer, Metastasis, Biology and Treatment: Electric Cell-Substrate Impedance Sensing in Cancer and Cancer Metastasis Research
  • 2006
    On the mechanism of sequence-specific DNA-dependent acetylation of p53: The acetylation motif is exposed upon DNA binding., Journal of Molecular Biology.

Grants and Contracts

  • 2016
    Artificial Sweeteners reduce Diabetes-Induced Vascular Permeability through Sweet Taste Receptor Signalling Pathways
    Role:
    Principal investigator
    Funding Source:
    Diabetes UK
  • 2016
    Artificial Sweeteners reduce Diabetes-Induced Vascular Permeability through Sweet Taste Receptor Signalling Pathways
    Role:
    Principal investigator
    Funding Source:
    Wellcome Trust
  • 2013
    Mechanisms Regulating the Pulmonary Endothelium through VE-Cadherin Trafficking
    Role:
    Principal investigator
    Funding Source:
    American Heart Association