Jakob's research is mainly in philosophy of mind and in cognitive science. He conducts research on the traditional mind-body debate as well as more interdisciplinary areas such as philosophy of cognitive neuroscience and philosophical psychopathology. He is involved in a number of experimental, interdisciplinary research projects with neuroscientists and psychiatrists and has built up a laboratory where he and his collaborators conduct experiments using neuroscience and psychology methods to address philosophical issues, and vice versa.