For the past 20 years, I have been both a clinical pediatric neuro-oncologist as well as a lab-based neuro-oncology researcher. My focus has been on the connections between normal brain development and the risk for brain tumor formation. More specifically, we are highly focused on the impact of normal sexual differentiation of the brain on rates and outcomes for males and females with malignant brain tumors. More males develop malignant brain tumors than females and males die faster and more frequently from their malignant brain tumors than do females. It is our goal to understand enough about the biology of sex differences in brain tumors to support the development of sex-specific approaches to brain tumor treatments. We expect that this will I'm prove outcomes for everyone.