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Magdalene Montgomery

NHMRC CDF Fellow, Senior Research Fellow, Head Metabolic Crosstalk Laboratory, The University of Melbourne

I am a NHMRC Career Development Fellow and Head of the Metabolic Crosstalk Laboratory at the University of Melbourne, with a focus on the pathogenesis of type 2 diabetes. I did my undergraduate studies in Germany (Philipps University Marburg) and my PhD in Australia at the University of Wollongong, graduating in 2011. Since then, I focussed on understanding the pathogenesis of insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD), initially at the Garvan Institute of Medical Research (Sydney, 2011-2013), followed by UNSW Sydney (2013 - 2016) and Monash University Melbourne (2016 - 2018). My research program focusses on identifying novel therapeutic targets for non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
I have an international reputation as expert in the diabetes and NAFLD field, which is evidenced by repeated invitations to present my research at international meetings (e.g. 2020 Keystone Symposia Canada, 2019 Cold Spring Harbor Laboratories New York), substantial editorial responsibilities (journals - Biochemical Pharmacology, Frontiers in Endocrinology, Biology) and grant review (NHMRC, Diabetes Australia), among others.

Experience

  • –present
    NHMRC CDF Fellow, Senior Research Fellow, Head Metabolic Crosstalk Laboratory, University of Melbourne
  • 2016–2018
    NHMRC CDF Fellow, Monash University
  • 2013–2016
    NHMRC ECF Fellow, UNSW Sydney
  • 2011–2013
    Postdoctoral fellow, Garvan Institute of Medical Research, Sydney

Education

  • 2011 
    University of Wollongong, PhD, Biomedical Sciences
  • 2008 
    Philipps-Universitaet Marburg, Germany, BSc (Hons)

Publications

  • 2020
    Molecular regulators of lipid metabolism in the intestine – underestimated therapeutic targets for obesity? , Dávalos-Salas M, Mariadason JM, Watt MJ, Montgomery MK (2020) Biochem Pharmacol 178:114091
  • 2020
    Inter-organelle communication in the pathogenesis of mitochondrial dysfunction and insulin resistance. , Keenan SA, Watt MJ, Montgomery MK (2020) Current Diabetes Rep 20(6):20
  • 2020
    SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycaemic control. , Montgomery MK, Bayliss J, Devereux C, Bezawork-Geleta A, Roberts D, Huang C, Schittenhelm RB, Ryan A, Townley SL, Selth LA, Biden TJ, Steinberg GR, Samocha-Bonet D, Meex RCR, Watt MJ (2020) Science Transl Med 10.1126/scitranslmed.aaz8048
  • 2019
    Regulation of mitochondrial metabolism in murine skeletal muscle by the medium chain fatty acid receptor Gpr84. , Montgomery MK, Osborne B, Brandon AE, O’Reilly L, Fiveash CE, Brown SHJ, Wilkins BP, Samsudeen A, Yu J, Devanapalli B, Hertzog A, Tolun AA, Kavanagh T, Cooper AA, Mitchell TW, Biden TJ, Smith NJ, Cooney GJ, Turner N (2019) FASEB J 33(11):12264-12276
  • 2019
    The liver as an endocrine organ - linking NAFLD and insulin resistance. , Watt MJ, Miotto PM, De Nardo W, Montgomery MK (2019) Endocrine Reviews 40(5):1367-1393
  • 2019
    Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe? , Montgomery MK (2019) Biology (Basel) 8(2) pii: E33.
  • 2019
    The role of Ap2a2 in PPARα-mediated regulation of lipolysis in adipose tissue. , Montgomery MK, Bayliss J, Keenan S, Rhost S, Ting SB, Watt MJ (2019) FASEB J 33(12):13267-13279
  • 2019
    Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity., Dávalos-Salas M, Montgomery MK, Reehorst CM, Nightingale R, Anderton H, Al-Obaidi S, Lesmana A, Ng I, Scott CM, Ioannidis P, Kalra H, Keerthikumar S, Tögel L, Rigopoulos A, Gong SJ, Williams DS, Yoganantharaja P, Bell-Anderson K, Mathivanan S, Gibert Y, Hiebert S, Scott AM, Watt MJ, Mariadason JM (2019) Nature Commun 10(1):5291
  • 2019
    Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. , Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomery MK, Papargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA (2019) Sci Trans Med 11(478). pii: eaau5758
  • 2019
    Perilipin 5 deletion in hepatocytes remodels lipid metabolism and causes hepatic insulin resistance in mice. , Keenan SN, Meex RC, Lo JCY, Ryan A, Montgomery MK, Watt MJ (2019) Diabetes 68(3):543-555
  • 2019
    Choline administration attenuates dystrophic pathology in mdx mice. , Alves FM, Caldow MK, Trieu J, Naim T, Montgomery MK, Watt MJ, Lynch GS, Koopman R (2019) Clinical Nutrition Experimental 24 (83-91)
  • 2019
    Impact of Lipotoxicity on Tissue "Cross Talk" and Metabolic Regulation. , Montgomery MK, De Nardo W, Watt MJ (2019) APS Physiology 34(2):134-149
  • 2018
    Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration. , Weston-Green K, Babic I, de Santis M, Pan B, Montgomery MK, Mitchell T, Huang XF, Nealon J (2018) Journal of Biomedical Science 2;25(1):40
  • 2018
    Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice. , Bentley N, Fiveash C, Osborne B, Quek L, Ogura M, Inagaki N, Cooney GJ, Polly P, Montgomery MK, Turner N (2018) Biochem Biophys Res Commun 503(3):1349-1355
  • 2018
    A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. , Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo J, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS (2018) Nature Commun 9(1):3165
  • 2018
    Perilipin 5 deletion in skeletal muscle unmasks an endoplasmic reticulum – fibroblast growth factor 21 axis for glycemic control. , Montgomery MK, Mokhtar R, Bayliss J, Bruce CR, Watt MJ (2018) Diabetes 67(4):594-606.
  • 2017
    Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains. , Montgomery MK, Brown SHJ, Mitchell TW, Coster ACF, Cooney GJ, Turner N (2017) Sci Rep 7(1):13914.
  • 2016
    Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. , Montgomery MK, Brown SHJ, Lim XY, Fiveash CE, Braude JP, Mitchell TW, Coster ACF, Don AS, Cooney GJ, Schmitz-Peiffer C, Turner N (2016) BBA Lipids 1861(11):1828-183
  • 2016
    The role of mitochondrial sirtuins in health and disease. , Osborne B, Bentley NL, Montgomery MK, Turner N (2016) Free Radic Biol Med 100:164-174
  • 2016
    Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training. , Mohktar RAM, Montgomery MK, Murphy RM, Watt MJ (2016) Am J Physiol Endocrinol Metab 311(1):E128-37
  • 2015
    Disparate metabolic response to fructose feeding between different mouse strains, Montgomery MK, Fiveash CE, Braude JP, Osborne B, Brown SHJ, Mitchell TW, Turner N (2015) Sci Rep 22;5:18474
  • 2015
    Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver. , Chowdhury K, Montgomery MK, Morris M, Cognard E, Shepherd P, Smith G (2015) Arch Physiol Biochem 121(3):88-96
  • 2015
    ID proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in beta-cells. , Bensellam M, Montgomery MK, Luzuriaga J, Chan JY, Laybutt DR (2015) Diabetologia 58(4):758-70
  • 2015
    Mitochondrial Dysfunction and Insulin Resistance – An update., Montgomery MK, Turner N (2015) Endocr Connect 4(1): R1 - R15
  • 2014
    PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. , Liu M, Montgomery MK, Fiveash C, Osborne B, Cooney GJ, Bell-Anderson K, Turner N (2014) Sci Rep 4:5538
  • 2013
    Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle. , Montgomery MK, Osborne B, Brown SH, Small L, Mitchell TW, Cooney GJ, Turner N (2013) J Lip Res 54(12):3322-33
  • 2013
    Declining NAD+ induces a pseudohypoxic state that disrupts nuclear-mitochondrial communication during aging. , Gomes AP, Price NL, Ling AJY, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann C, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Spiegelman BM, Kaelin Jr. WG, Turner N, Bell EL, Sinclair DA (2013) Cell 155(7): 1624–1638
  • 2013
    Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding, Montgomery MK, Hallahan NL, Brown SH, Liu M, Mitchell TW, Cooney GJ, Turner N (2013) Diabetologia 56(5):1129-39
  • 2012
    Does the oxidative stress theory of aging explain longevity differences in birds? I. Mitochondrial ROS production. , Montgomery MK, Hulbert AJ, Buttemer WA (2012) J Exp Ger 47(3):203-10
  • 2012
    Does the oxidative stress theory of aging explain longevity differences in birds? II. Antioxidant systems and oxidative damage. , Montgomery MK, Hulbert AJ, Buttemer WA (2012) J Exp Ger 47(3):211-22
  • 2012
    Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl. , Montgomery MK, Hulbert AJ, Buttemer WA (2012) J Comp Physiol B 182(1):127-37
  • 2011
    The long life of birds: The rat-pigeon comparison revisited. , Montgomery MK, Hulbert AJ, Buttemer WA (2011) PloS One 6(8):e24138
  • 2010
    Membrane fatty acid composition and longevity of mammals and birds. Chapter in book: “Longevity, mitochondria and oxygen free radicals” (ISBN: 978-81-308-0415-6, Editors: Reinald Pamplona and Gustavo Barja), Hulbert AJ, Trzcionka M, Buttemer WA (2010)
  • 2008
    The effects of fasting and cold exposure on metabolic rate and mitochondrial proton leak in liver and skeletal muscle of an amphibian, the cane toad Bufo marinus, Trzcionka M, Withers K, Jastroch M, Klingenspor M (2008) J Exp Biol 211(Pt 12):1911-8
  • 2008
    An ancient look at UCP1. , Klingenspor M, Fromme T, Hughes DA Jr, Manzke L, Polymeropoulos E, Riemann T, Trzcionka M, Hirschberg V, Jastroch M. (2008) Biochim Biophys Acta 1777(7-8):637-41

Grants and Contracts

  • 2020
    Faculty of Medicine, Dentistry and Health Sciences RGGS Research Grants Scheme
    Role:
    CIA
    Funding Source:
    University of Melbourne
  • 2018
    NHMRC CDF Fellowship
    Role:
    CIA
    Funding Source:
    National Health and Medical Research Council
  • 2018
    NHMRC Project Grant
    Role:
    CIB
    Funding Source:
    National Health and Medical Research Council
  • 2017
    FMNHS Advancing Women in Research Grants
    Role:
    CIA
    Funding Source:
    Monash University
  • 2017
    Faculty of Medicine, Nursing and Health Sciences (FMNHS) Strategic Grants Scheme (SGS)
    Role:
    CIA
    Funding Source:
    Monash University
  • 2016
    Diabetes Australia General Grant
    Role:
    CIB
    Funding Source:
    Diabetes Australia
  • 2014
    NMRC Project Grant
    Role:
    CID
    Funding Source:
    National Health and Medical Research Council
  • 2014
    NHMRC Peter Doherty Early Career Fellowship
    Role:
    CIA
    Funding Source:
    National Health and Medical Research Council

Professional Memberships

  • Australian Diabetes Society
  • American Physiological Society
  • European Association for the Study of Diabetes
  • Australian Physiological Society

Research Areas

  • Biochemistry And Cell Biology (0601)
  • Medical Biochemistry And Metabolomics (1101)
  • Medical Physiology (1116)