Marie Gernigon

Research interest :
My work focused on the consequences of dioxygen (O2) deficit as a limiting factor of exercise in trained and diseased participants.
Despite the importance to characterize the plateau of maximal oxygen uptake (i.e., VO2max) in order to state that the exercise is maximal, the literature reports dissonances in its prevalence i.e., 0 to 90% depending on studies. The origin of this variability in plateau prevalence is multifactorial. Thus, one part of my work aims to assess the factors limiting maximum performance in the healthy and trained participants.
I am also interested in the functional consequences of an O2 deficit in walking. Indeed, the patient with peripheral arterial dysfunction (Peripheral Arterial Diseased, PAD) may exhibit walking functional discomfort due to exercise induced ischemia. The evaluation of the Maximum Walking Distance (MWD) represents a crucial issue since a MWD of less than 300 meters is in favor of a revascularization. Therefore, the other aim of my work is to test the validity of innovative methodologies based on Global Positioning System (GPS) and Transcutaneous Pressure in Oxygen (TcPO2) during a treadmill test with respect to the assessment of the functional limitation in PAD patients.

Laboratory affiliations :
1 - CIAMS, Université Paris-Saclay, 91405 Orsay Cedex, France
2 - CIAMS, Université d'Orléans, 45067, Orléans, France