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Lecturer in the Biology of Ageing, University of Kent

Marina Ezcurra received her PhD from the Karolinska Institute in 2011. Her PhD research was a collaborative project between Karolinska and MRC-LMB, Cambridge, and she studied neural circuits and behavior using C. elegans in Bill Schafer’s group. During her PhD, Marina Ezcurra identified extrasynaptic mechanisms by which nutritional status modulates nociception, involving neuropeptidergic and dopaminergic signaling. She went on to do a postdoc working on ageing with David Gems at University College London. During her postdoc, Marina Ezcurra developed methods to monitor the development of multiple age-related diseases in vivo in C. elegans, leading to the discovery of a previously unknown process, Intestinal Biomass Conversion. This mechanism enables the C. elegans intestine to be broken down to produce vast amounts of yolk, resulting in polymorbidity and mortality in ageing nematodes. This work illustrates how ageing and age-related diseases can be the result of run-on of wildtype gene function rather than stochastic molecular damage. Current research in Marina Ezcurra’s group focuses on how host-microbiome interactions affect host ageing and is funded by The Wellcome Trust and Royal Society. Marina Ezcurra is a trustee board members of The British Society of Research on Ageing.

Experience

  • –present
    Lecturer in the Biology of Ageing, University of Kent