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Nial Wheate

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Associate Professor of the School of Pharmacy, University of Sydney

Associate Professor Wheate completed a Bachelor of Science (BSc) degree with 1st class honours from the University of New South Wales whilst at the Australian Defence Force Academy. He then completed a Doctor of Philosophy (PhD) in medicinal chemistry under Professor J. Grant Collins. Since then he has worked in the School of Biomedical and Health Sciences at the University of Western Sydney (Australia) and the Strathclyde Institute of Pharmacy and Biomedical Science (Scotland) before taking up a position in the Faculty of Pharmacy at the University of Sydney (Australia) in 2012.

Associate Professor Wheate was awarded a Doctor of Science (DSc) in 2020 and a Master of Business Administration (MBA in 2021 both from The University of Sydney.

Associate Professor Wheate was previously the Program Director of the pharmacy undergraduate degrees at The University of Sydney and the Head of Cancer Research in the Faculty of Pharmacy.

Awards
The Australian Research Awards 2023, Best in Field (Inorganic Chemistry)
Senior Fellow, Higher Education Academy, 2019
Royal Australian Chemical Institute Nyholm Lecturer, 2018

Experience

  • 2018–present
    Associate Professor, University of Sydney
  • 2012–2017
    Senior Lecturer, University of Sydney
  • 2007–2011
    Lecturer, University of Strathclyde
  • 2005–2007
    Senior Research Fellow, University of Western Sydney
  • 2002–2005
    Lieutenant, Royal Australian Navy
  • 2001–2002
    Associate Lecturer, University of New South Wales
  • 1999–2001
    Sub-Lieutenant, Royal Australian Navy
  • 1995–1998
    Midshipman, Royal Australian Navy

Education

  • 2021 
    University of Sydney, MBA
  • 2020 
    University of Sydney, DSc
  • 2002 
    University of New South Wales, PhD
  • 1998 
    University of New South Wales, BSc (Hons I)
  • 1997 
    Australian Defence Force Academy, Graduate

Publications

  • 2021
    Microplastic in pharmaceutical dosage forms and patient informed consent, Australian Journal of Medical Sciences
  • 2021
    Macrocycles as drug-enhancing excipients in pharmaceutical formulations, Journal of Inclusion Phenomena and Macrocyclic Chemistry
  • 2021
    Opioid exposures in children under 5 years of age (2004–2019):A retrospective study of calls to Australia’s largest poisonsinformation centre, Journal of Paediatrics and Child Health
  • 2021
    An analysis for adulteration and contamination of over-the-counter weight-loss products, AAPS PharmSciTech
  • 2020
    Demonstration of the first known 1:2 host‑guest encapsulation of a platinum anticancer complex within a macrocycle, Journal of Inclusion Phenomena and Macrocyclic Chemistry
  • 2019
    Analysis of the interaction of para-sulfonatocalix[8]arene with free amino acids and a six residue segmentof β-amyloid peptide as a potential treatment for Alzheimer’s disease, Journal of Inclusion Phenomena and Macrocyclic Chemistry
  • 2018
    The side effects of platinum-based chemotherapy drugs: a review for chemists, Dalton Transactions
  • 2018
    An evaluation of garlic products available in Australian pharmacies–From the label to the laboratory, Journal of Herbal Medicine
  • 2018
    Patterns of platinum drug use in an acute care setting: a retrospective study, Journal of Cancer Research and Clinical Oncology
  • 2018
    Demonstration of In Vitro Host-Guest Complex Formation and Safety of para-Sulfonatocalix[8]arene as a Delivery Vehicle for Two Antibiotic Drugs, Journal of Pharmaceutical Sciences
  • 2017
    Determining the Ibuprofen Concentration in Liquid-Filled Gelatin Capsules To Practice Collecting and Interpreting Experimental Data, and Evaluating the Methods and Accuracy of Quality Testing, Journal of Chemical Education
  • 2017
    Comparative macrocycle binding of the anticancer drug phenanthriplatin by cucurbit[n]urils, β-cyclodextrin and parasulfonatocalix[ 4]arene: a 1H NMR and molecular modelling study, Journal of Inclusion Phenomena and Macrocyclic Chemistry
  • 2016
    Cucurbit[n]urils as excipients in pharmaceutical dosage forms, Supramolecular Chemistry
  • 2016
    Loading of a Phenanthroline-Based Platinum(II) Complex onto the Surface of a Carbon Nanotube via pi–pi Stacking, Australian Journal of Chemistry
  • 2016
    Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs, Journal of Pharmaceutical Sciences
  • 2016
    Executive functions predict conceptual learning of science, British Journal of Developmental Psychology
  • 2015
    The state-of-play- and future of platinum drugs, Endocrine-Related Cancer
  • 2015
    Cucurbit[7]uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model, Journal of Ovarian Research
  • 2014
    Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery, Inorganica Chimica Acta
  • 2014
    Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents, Journal of Visualized Experiments
  • 2014
    The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles, Toxicology Research
  • 2014
    Chemical factors affecting cucurbit[n]uril formulation into ocular dosage forms: excipient binding, solubility, corneal permeability and antibiotic encapsulation, Supramolecular Chemistry
  • 2014
    Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril, PLoS One
  • 2014
    A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol, Journal of Inorganic Biochemistry
  • 2013
    DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex, Journal of Inorganic Biochemistry
  • 2013
    Platinum anticancer drugs, Encyclopedia of Metalloproteins
  • 2013
    Evidence for a Role of Executive Functions in Learning Biology, Infant and Child Development
  • 2012
    Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect, Metallomics
  • 2012
    Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields, Inorganica Chimica Acta
  • 2012
    Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity, Dalton Transactions
  • 2012
    Nanoparticles: the future for platinum drugs or a research red herring?, Nanomedicine
  • 2012
    Cisplatin-Tethered Gold Nanoparticles That Exhibit Enhanced Reproducibility, Drug Loading, and Stability: a Step Closer to Pharmaceutical Approval?, Inorganic Chemistry
  • 2012
    Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A, Chemical Science
  • 2012
    Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery, Pharmaceutical Research
  • 2012
    Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene, Inorganica Chimica Acta

Professional Memberships

  • Fellow and Chartered Chemist of the Royal Australian Chemical Institute
  • Member of the Australian Institute of Company Directors
  • Senior Fellow of the Higher Education Academy

Research Areas

  • Pharmacology And Pharmaceutical Sciences (1115)
  • Medicinal And Biomolecular Chemistry (0304)

Honours

Australian Defence Medal (2007), National Medal - Australia (2017)