Head of Cancer, Ageing and Somatic Mutation, Wellcome Trust Sanger Institute

I am a scientist at the Wellcome Sanger Institute who is interested in mutations in cancer and normal cells.

My research programme focuses on the genetic changes our cells acquire as we go through life, and how these mutations are related to ageing, cancer and other disease processes.

My major interest is in cancer genomics, and in particular genome-wide analyses of somatic mutations in tumours, as well as: the discovery of new cancer genes; the identification of somatic mutation processes operative in tumours; the characterisation of patterns of cancer evolution; and the translation of these fundamental insights about cancer biology into better management of patients. I am increasingly interested in the role of somatic mutations outside of cancer. Particular focus areas include how somatic mutations delineate clonal relationships of normal cellular populations and how somatic mutations affect normal cellular behaviour.

Experience

  • 2010–2020
    Group Leader, Wellcome Sanger Institute