Sajish Mathew

My interest is to understand the molecular basis of diseases caused by metabolic dysfunction like diabetes, cancer and Alzheimer’s disease. My current focus is on the non-translational functions of aminoacyl tRNA synthetases (the amino acid binding proteins) to understand how the amino acids are involved in glucose homeostasis. We believe that elucidation of the functional role of aminoacyl tRNA synthetases in the regulation of metabolic flux will shed light on the etiology of various metabolic diseases and will provide novel strategies to tackle metabolic dysfunctions.