Dr Vanessa Bryant’s research aims to solve the underlying genomic and functional causes of rare disorders of the immune system, focusing on the variable disorder Common Variable Immunodeficiency (CVID), both as a primary immunodeficiency in itself, and as a model for other complex immune disorders. Dr Bryant’s research combines functional genomics with quantitative immunology to transform the way we approach and treat rare and complex immune diseases. Her research has identified novel CVID genes and mutations responsible for disease, including discovery NFB1 deficiency, now recognised as the largest cause of single-gene cause of CVID. Dr Bryant is the inaugural Sir Clive McPherson Family Research Fellow and a Royal Melbourne Hospital DW Keir Fellow. She is a Laboratory Head in the Immunology Division at the Walter and Eliza Hall Institute and Clinical Scientist at The Royal Melbourne Hospital. Her clinical genomics programs with the Immunology Flagship programs of Melbourne Genomics and Australian Genomics are aimed to implement early, accurate gene-based diagnoses for people with suspected rare primary immunodeficiency to allow early and targeted care and avoid the complications of unmanaged disease. Dr Bryant also co-leads COVID PROFILE, a longitudinal clinical study of immunity to COVID-19.