A nurse prepares medication for a patient in the TACTIC-R clinical trial at Addenbrooke’s Hospital in Cambridge, England, May 21, 2020.
What prompts healthy volunteers to take part in clinical research? And how are they protected?
It can be painful for researchers to read harshly worded criticism of their work from peer reviewers.
Peer review of research sounds like it should be a conversation between equals. Instead, it can be patronizing, demanding and simply unkind. A group of journal editors thinks this should change.
Until recently, most biomedical studies did not consider sex or gender.
Biomedical studies have traditionally used male animals and men as research subjects. That is a problem for everyone because for many diseases, there are sex differences in how they affect people.
Preclinical research — the kind that takes place before testing on humans — often guides decisions about which potential treatments should continue to clinical trials. But attempts to replicate 50 studies found the odds of getting the same results were only about 50-50.
Preclinical studies are an important part of biomedical research, often guiding future trials in humans. Failure to replicate research results suggests a need to increase the quality of studies.
A researcher works with COVID-19 samples from patients.
Thomas Samson/AFP via Getty Images
Careful lab work will complement public health data as researchers worldwide focus on omicron, asking questions about contagiousness, severity of disease and whether vaccines hold up against it.
Professor Tania Douglas is warmly remembered as an excellent scientist and a remarkable human being.
Je'nine May/UCT Health Sciences
She believed and advocated that Africa needs to find solutions to its own problems and worked tirelessly to build biomedical engineering capacity across the continent.
Pigs with human immune systems.
Medical research to benefit people is first conducted in animals. Creating a new biomedical model by inserting human immune cells into pigs may lead to new insights and treatments.
While COVID-19 has highlighted the invaluable nature of medical research, it has unfortunately also seriously disrupted it. In Australia, the sector now teeters on the brink of collapse.
People wearing masks walk in front of Pfizer’s headquarters in New York City. Pfizer and BioNtech are on track with a vaccine that is 90 per cent effective, say preliminary results, but they are not the only ones in the race.
AP Photo/Bebeto Matthews
Canada has set aside a total of 414 million doses of different types of vaccine. Some exploit known mechanisms, others are based on previously untested approaches.
Light is key to ultrasensitive chemical sensors.
Kwanchai Lerttanapunyaporn/EyeEm via Getty Images
An optical sensor that can detect individual molecules promises early detection of diseases and environmental contamination.
An artificial respirator made by Both Equipment Ltd, Adelaide, South Australia, 1950-1959.
Drawing thoughtfully on the Powerhouse Museum’s collection, this exhibition lovingly exposes the humanity behind biomedical technology.
Duck decoys lure real ducks within range of hunters. Nanoparticles that look like cells serve as both decoys and hunters to ensnare virus particles.
Nanoparticles dressed up in cell membranes snag SARS-CoV-2 virus particles before they reach human cells.
A cutting edge new research project is developing Lego-like bricks made from biomaterials to replace bone fragments in shattered limbs.
Artificial intelligence can do what humans can’t – connect the dots across the majority of coronavirus research.
baranozdemir/E+ via Getty Images
The scientific community is churning out vast quantities of research about the coronavirus pandemic – far too much for researchers to absorb. An AI system aims to do the heavy lifting for them.
A number of young COVID-19 patients have developed inflammation in multiple organs.
Ezra Acayan/Getty Images
A biomedical researcher and pediatrician who works with Kawasaki disease and COVID-19 explains the similarities and differences in the worrisome cases doctors are starting to see.
Traditional approaches to biomedical research and development are costly and time consuming.
Crowdsourcing is a promising approach to biomedical research and development (R&D) and could produce solutions to pandemics like this one.
Monaco and Japan have some of the highest life expectancies in the world. But calculating an individual’s life expectancy will require taking data analysis several steps further.
Predicting life expectancy remains in the realm of science fiction, but it may soon be possible. Are we prepared for such information? And who else would benefit from this knowledge?
A few woefully underfunded academic health sciences centres are responsible for providing complex care to patients with life-threatening illnesses as well as training future doctors and testing the latest in new surgical techniques.
Canada’s systems of health funding, medical training and physician compensation need an overhaul – to support vital centres of medical research and complex care.
It takes time to see which finding might be a golden egg.
Basic research can be easy to mock as pointless and wasteful of resources. But it’s very often the foundation for future innovation – even in ways the original scientists couldn’t have imagined.
It may take time for a tiny step forward to show its worth.
Scientists are rewarded with funding and publications when they come up with innovative findings. But in the midst of a ‘reproducibility crisis,’ being new isn’t the only thing to value about research.