Pan-assay interference compounds, or PAINS, often come up as false positives when researchers screen for potential drug candidates.
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While technological advancements have quickened the drug discovery process, some chemical compounds remain a common thorn in a researcher’s side.
Nearly 80% of participants in FDA-reviewed research trials live in foreign countries.
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Regulatory loopholes for research conducted off US soil allow for questionable trials and misleading data to slip under the FDA’s radar.
Bacteria that are resistant to every available antibiotic in the U.S. already exist.
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If no action is taken to address antibiotic resistance, infections from multidrug-resistant bacteria could cause 10 million deaths each year by 2050.
The path to using old drugs for COVID is full of potholes. So why are we using the same old flawed methods when we actually know what works?
The subtleties of how genes are transcribed into RNA molecules like the one depicted here are key to understanding the inner workings of cells.
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Machine learning is great at finding patterns but doesn’t know what those patterns mean. Combine it with knowledge gained from genetic research and you have a powerful view into the workings of cells.
The pipes imprinted on microfluidic chips are about the size of a human hair, and in many ways are like miniaturizing a chemical manufacturing plant.
Artificial cells on tiny microfluidic chips can provide early insight into how new cancer drugs behave in cells, and why certain kinds of cancer are more resistant to chemotherapy treatment.
Gene-based vaccines had never been approved for humans before the coronavirus pandemic.
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The coronavirus pandemic has driven a lot of scientific progress in the past year. But just as some of the social changes are likely here to stay, so are some medical innovations.
It takes a tremendous amount of computing power to simulate all the components and behaviors of viruses and cells.
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Scanning through billions of chemicals to find a few potential drugs for treating COVID-19 requires computers that harness together thousands of processors.
Testing in cells is an important and exciting first step.
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Researchers at the University of California, San Francisco, identified nine existing drugs that show promise to treat COVID-19. The proteins they target haven’t been tried before.
There are 20,000 FDA approved drugs. One of them might fight COVID-19, if we can find it.
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Among the more than 20,000 drugs approved by the FDA, there may be some that can treat COVID-19. A team at the University of California, San Francisco, is identifying possible candidates.
A colored electron microscope image of MRSA.
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Pathogens rapidly evolve resistance to antibiotics. AI could keep us a step ahead of deadly infections.
Drug discovery can get an assist from what nature’s already devised.
As antibiotic resistance increases globally, the heat is on to find new alternatives to treat infections. Chemists can get a head start by looking at compounds produced in nature by fishes’ microbes.
The concept of a shared inheritable risk underlying mental illnesses could lead to a new paradigm shift in drug discovery,
Mental health is impacted by both genetic and environmental factors. But new research reveals that many mental health disorders may flow from early disturbances in fetal development.
Around 18% of previously treated TB cases are drug resistant.
Using a large number of computers to screen TB drugs reduces the cost and time.
Alzheimer’s disease is the most common form of dementia.
People with Down syndrome are at much higher risk of dementia than the general population. Knowing when cognitive changes start is critical for developing new drugs.
Miniature biomanufacturing kits like this prototype could revolutionize the pharmaceutical industry.
Small-batch brewers are starting to tinker with biologic drugs to meet their own medical needs. A side effect of their success would be a disruption to how big pharma makes and distributes drugs.
People have to pass road tests – so should self-driving cars.
There’s a common, popular and well-studied method to ensure new technologies are safe and effective for public use – even if researchers don’t fully understand how they work.
High-tech ways to scan nature’s own creations.
Pharmaceutical companies focus on small molecules they’ve devised – and can easily patent. But nature’s already come up with many antibacterial compounds that drug designers could use to make medicines.
Will blue packets replace pink ones soon?
Medicinal chemists are tweaking a natural molecule that can be a deadly poison – a modified version might work as a nonhormonal male contraceptive.
Moving a robot is like manipulating a molecule.
Researchers use an algorithm designed to help robots move to figure out what’s possible when designing new molecules in a promising class of pharmaceuticals.