There are many scientific and ethical challenges ahead. But these types of trials have helped in the development of vaccines against a few diseases. Could they do the same for COVID-19?
Lockdown is a drastic solution to limit the impact of COVID-19 and has many costs, as this long read explains.
There’s a faster way to complete vaccine trials, but is it ethical?
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Challenge trials – purposefully exposing volunteers to the coronavirus – could speed up the development of a vaccine. But there are serious ethical concerns with this approach.
Indian health workers doing health checks in Mumbai, June 17, 2020.
AP Photo/Rafiq Maqbool, File
The high cost of pharmaceuticals often means only the richest patients get lifesaving medicines. As coronavirus drugs emerge, it will require hard, creative work to ensure they're available to all.
The Statue of Liberty.
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A bioethicist argues that the problem of health disparities existed long before COVID-19 struck with a vengeance in marginalized communities.
The Canadian Hospice Palliative Care Association is calling on health authorities to “implement a more compassionate approach to end-of-life visitations … during the COVID-19 pandemic.”
Preventing people from dying alone in a pandemic takes ingenuity and money, but it’s the right thing to do.
A researcher performs a CRISPR/Cas9 process at the Max-Delbrueck-Centre for Molecular Medicine in Germany .
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One of the methods researchers are exploring to combat COVID-19 is gene editing: altering the genome of the virus to make it harmless.
Modern day research and clinical trials are highly regulated.
To refuse inclusion would prevent Africa’s researchers from being significant players in the universal fight against the virus.
Rather than basing decisions about ICU access on age, clinicians need to consider the potential benefits and burdens of treatments proposed for every patient.
We urgently need a vaccine for COVID-19 but exposing humans to a vaccine candidate that hasn't undergone the usual safety assessments is risky.
Ethical frameworks, rules, laws: all try to have their say.
CRISPR technology could have momentous effects if it's used to edit genes that will be inherited by future generations. Researchers and ethicists continue to weigh appropriate guidelines.
Human challenge studies can be useful to test new vaccines and are increasingly being used internationally. Yet there are several ethical issues to consider.
Deliberately infecting people with a disease-causing agent as part of carefully considered medical research can be ethically acceptable or even necessary.
He Jiankui claims he helped make the world’s first genetically edited babies: twin girls whose DNA he said he altered.
AP Photo/Mark Schiefelbein
News of the gene-edited babies excludes images of the children's mother. Cutting her out of the picture underscores the idea that the mother is obsolete and babies can be created in the lab.
What’s the best way to put the brakes on current research?
Scientists and ethicists have called for a five-year moratorium on editing human genes that will pass on to future generations. Yes, society needs to figure out how to proceed – but is this the best way?
Experts have called for a moratorium on clinical research with CRISPR/Cas9 gene editing.
of the germline — that is changing heritable DNA in sperm, eggs or embryos to make genetically modified children.
CRISPR gene editing should learn from the Slow Food movement. Scientists must allow time for critical conversations and perfecting of techniques before rewriting the source code of humanity.
An African American man in a hospital bed. Studies show that pain in African American patients is often not addressed.
Gaps in care and outcomes between African-Americans and white patients is a major concern to those who care about fairness in health care. Gaps in care also exist at end of life, too.
Can’t sleep: these cloned macaque monkeys are missing a gene involved in regulating the sleep/wake cycle.
Chinese Academy of Sciences via AAP
Researchers in China have produce a world first: gene edited, cloned macaque monkeys. They say such animals will be vital for research on human health – but ethical concerns remain.
Bacteriophage viruses infecting bacterial cells , Bacterial viruses.
Gene editing through CRISPR may have greater consequences than climate change or unleashing the energy of the atom.
What does oversight really ensure?
Questions abound about whether the scientist who created the first gene edited human beings took shortcuts in the ethical oversight process. But pedantically focusing on protocol misses the point.
He Jiankui, a Chinese researcher, speaks during the Human Genome Editing Conference in Hong Kong, Nov. 28, 2018. He made his first public comments about his claim of making the world’s first gene-edited babies.
AP Photo/Kin Cheung
Chinese researcher He Jiankui told a spellbound audience how he created gene-edited babies. With a couple of revealing slides, we can see what he did and speculate what health problems might ensue.