Human intelligence: why are we the smartest primates?

Intelligence is our most complex characteristic. Some would even say it defines us, setting us apart from other primates. And now, a new study – published this week by Hennady P. Shulha and colleagues in PLOS Biology – brings us a step closer to explaining the genetic and evolutionary basis of human…

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The human brain can write plays and build robots, but where did this intelligence come from? ores2k

Intelligence is our most complex characteristic. Some would even say it defines us, setting us apart from other primates. And now, a new study – published this week by Hennady P. Shulha and colleagues in PLOS Biology – brings us a step closer to explaining the genetic and evolutionary basis of human intelligence.

To understand the significance of this research, we need to take a step back and consider some basic genetics.

The genome project

The human genome was sequenced a decade ago, but we still don’t have much idea about how it works. That is, we understand how genes encode proteins, and that mutations in genes sometimes make defective proteins that cause disease.

But, for the most part, we can’t track complex human characteristics back to any genetic explanation.

Most researchers would say that the 20,000-odd protein-coding genes encoded in the human genome are necessary but not sufficient to build the complexity of the organism they describe.

There are roughly 250 different types of cells that make up a human body, and the set of genes that is “expressed” (i.e. when a gene’s information is used in the synthesis of a functional gene product) in each cell type is different.

So there is clearly a complex mechanism controlling which genes are expressed where and when. Modern biologists increasingly believe this is where the real meat of the human genome project is.

baboon(TM)/Flickr

Understanding how genes are controlled, how they control each other, and how turning genes on and off in different places and at different times allows not just the building of a human from a single cell, but also the development of a human brain that can recognise itself, understand language, write plays and build robots to explore other planets.

And this is where epigenetics comes in.

Epigenetics

We know there are short DNA sequences located close to genes that affect how those genes are expressed. But DNA, it seems, isn’t just a long list of instructions that are read off, but rather is itself an active participant in the reading and interpretation of those instructions.

Parts of chromosomes (thread-like structures in the nuclei of cells, containing a DNA molecule) loop around to contact each other so often a region that controls a gene is some distance away.

Sometimes regions of the genome are wrapped up so the genes can’t be accessed and sometimes the DNA itself is chemically altered to make it more, or less, readable.

To make matters even more complicated, these different states of the DNA can often be inherited through cell division and even passed through generations.

As mentioned, the catch-all term used to describe these types of genomic activities is “epigenetic” – characteristics of the genome that affect and influence the expression of genes in time and space, so the same sequence of DNA can do different things in different contexts.

theqspeaks/Flickr

Altered histones

One common epigenetic “marker” is the chemical state of proteins which make up the superstructure around which DNA is wrapped.

These proteins, called histones, have various states which can be altered by adding and removing small methyl (CH3) groups. In turn, the methylation state of the histones around which a particular region of DNA is wrapped affects whether or not that region of DNA is expressed.

There are enzymes that add and remove the methylation groups, so one way of controlling lots of genomic regions in concert might be to increase an enzyme that changes the methylation state of particular histones.

You can see that this isn’t far off the idea of a master switch.

So different cells have the same genome sequence but different epigenetic interactions. If we want to find out how complex human characteristics are controlled at the molecular level, we need to look at the networks of epigenetic interactions that control genes, and try to track down those interactions that make certain cells behave in certain ways.

irishwildcat

New insights

Which brings us back to the new research published by Shulha and colleagues in PLOS Biology.

In their paper the researchers identified some of the epigenetic characteristics in DNA isolated from neuron cells in the prefrontal cortex of humans.

(The prefrontal cortex is an area of the brain associated with evolution of the primate brain, and, by inference, intelligence.)

By comparing the locations of a particular type of methylated histone called H3K4me3 (which is often found at the start site of regulated genes) between human, chimp and macaque neurons, they found several hundred regions in which humans appear to use the process of histone methylation to control areas which chimps and macaques don’t.

Why is this interesting? Because these may be the genomic areas that are involved in human brain functions, including intelligence.

Of course, humans, chimps and macaques are different in lots of ways (not just in intelligence). To address this, the authors showed that some of the regulatory regions they had identified were only found in human neurons, not in the cells surrounding neurons.

bigbear3001

Why?

The regions that are different between humans and monkeys might just relate to general differences between the species – e.g. regions that control tail growth – rather than ones responsible for brain functions.

The fact the regulatory regions were only found in neurons and not in non-neuron human cells probably means they are specific to neurons. And therefore, these regulatory regions are more likely to relate to brain differences rather than just species differences.

The researchers also showed that some of those regions they had identified were near genes known to be involved in neuropsychiatric disorders such as autism, schizophrenia and ADHD.

The basis of intelligence?

So we have a set of highly regulated DNA regions that are only found in prefrontal cortex neurons and are not found in less intelligent but closely related species. Furthermore, some of those regions are close to genes that are known to be involved in brain-related diseases.

And the regions all share a common control mechanism, leading us to think there may be some way of tweaking them as a group.

Sure, we’re still a long way off understanding the link between the genome and human physiology. But new tools which allow us to query epigenetic interactions are bringing us closer to being able to describe how different types of cells look and behave and why that might be the case.

In this way, the new research by Shulha and colleagues provides hints as to the genetic networks that control the development of higher-level functions such as human intelligence.

Andrew Lonie is a computational biologist and Head of the Life Sciences Computation Centre at the Victorian Life Sciences Computation Initiative hosted at the University of Melbourne, where he is also Co-ordinator of the Masters of Science in Bioinformatics.

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92 Comments sorted by

  1. Mark King

    Senior Lecturer, Psychology and Counselling and Researcher, CARRSQ at Queensland University of Technology

    An interesting article, Andrew. It seems the mechanisms behind natural selection are becoming ever more complicated, given your comment that "different states of the DNA can often be inherited through cell division and even passed through generations".

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    1. Dov Henis

      retired industrial consultant, PhD UPgh, PA USA

      In reply to Mark King

      Intelliget Life

      Life: mass format of evolving naturally selected RNA nucleotide(s), which is life’s primal organism.

      Natural selection: ubiquitous phenomenon of material that augments its energy constraint.

      Mass-Energy: inert-moving graviton(s), the fundamental particle of the universe, inert extremely briefly at the pre-big-bang singularity .

      Intelligence: learning from experience.

      Intelligent Life

      Life is an evolving system continuously undergoing natural selection i.e. continuously selecting, intelligently, opportunities to augment its energy constraint in order to survive i.e. in order to avoid/postpone its own mass format being re-converted to energy.

      Dov Henis

      (comments from 22nd century)

      http://universe-life.com/

      PS;
      Genomes are formed by/for the genes and are continuously modified by them...

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    2. Alex Cannara

      logged in via Facebook

      In reply to Mark King

      You never disappoint with desperate juvenility, eh Roy?
      ;]

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    3. Roy Niles

      logged in via Facebook

      In reply to Mark King

      Poor Alex, still blabbering away. It's not working for him.

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  2. Dale Bloom

    Analyst

    A species of animal is as intelligent as it needs to be in order to survive in its niche.

    However, animals often have more sophisticated sensory systems than humans, and human sensory systems are very primitive compared to many other species of animals.

    Therefore, comparing human intelligence to the intelligence of other animals is somewhat meaningless unless sensory systems are compared also.

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    1. Roy Niles

      logged in via Facebook

      In reply to Dale Bloom

      Dale is correct. As a physically weaker species, we developed better means of communicating with other humans to cooperate and survive. We developed a more complicated language and a better way to vocalize it, and in turn a newer section of the brain to handle a greater cultural capacity for sharing more abstract conceptions and more complicated behavior strategies. All of these relatively useful capacities must evolve together in any social species - and in a sense, all species have social ties to those that bear their members.

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    2. Dale Bloom

      Analyst

      In reply to Dale Bloom

      Roy Mills
      There could be an interesting situation developing in that modern humans, with their supposed intelligence and communication abilities are mostly suited to a man-made or artificial environment.

      An average Australian could not survive for more than a few days (or even a few hours) in the bush, and would quickly perish due to thirst, exhaustion or exposure.

      We now spend most of the day in man-made boxes or artificial environments such as in a house, office room or car (which is a box on wheels), and those man made environments have to be air-conditioned, rain proof, block out sunlight, and they often have muzak supplied. They must also be connected to an artificial energy supply such as an electricity grid.

      So in many ways, we are actually becoming more limited and less capable in time.

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    3. Roy Niles

      logged in via Facebook

      In reply to Dale Bloom

      Dale, the average Australian may not do too well in the bush, but the Aborigines there would prosper, and they are in that sense more "survivably" intelligent than the average. They can go to school and learn to do what the more literate among us do, but we have no schools to go to, in turn, to teach us to do what they have done almost instinctively.
      Apparently, if we don't practice what have become instinctive behaviors, over time we lose those instincts. My theory is of course that all instincts were initially learned, but those who believe they were granted to some of us who "fit" them by accident won't be likely to agree with the above.

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    4. Dale Bloom

      Analyst

      In reply to Dale Bloom

      Roy Niles,
      Yes, our definition of intelligence is totally subjective.

      We may consider ourselves intelligent and capable, but only within a particular environment, and the environment for humans is becoming more man-made or artificial.

      Outside of that man-made or artificial environment that we ourselves create, we may not be so intelligent or capable.

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    1. Danny Hoardern

      Analyst Programmer

      In reply to Danny Hoardern

      @Dale

      That study only relates to the adolescent brain, of course you should not consume cannabis or alcohol before legal age limits. For adults, it is a different story[1].

      Is it that hard to believe that being able to access more of our memories gave our species an edge? I hope this is not going down the spiral of reefer madness...

      Peace :)

      1. http://healthland.time.com/2011/07/19/study-marijuana-not-linked-with-long-term-cognitive-impairment/

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  3. Kim Peart

    Researcher & Writer

    In considering the driver of humans, the DNA, as described here, is it possible to consider the outcome that we are without taking into account the primal causes?

    We currently have no idea what went on before the Big Bang, or if we can even use our brains to think about that, as we are told information only began with the beginning of the cosmos with an expanding singularity, but we can know through simple observation, that the laws of Nature were in full working order at the beginning.

    We…

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    1. David Paxton

      Veterinarian

      In reply to Kim Peart

      Kim, thank you for your reply to my comment on Andrew's paper. May I recommend Peter MacNeilage's readable and persuasive book - The Origin of Speech, Oxford University Press, Cambridge, 2009 - where he argues that the physical capacity to enunciate words would have evolved step-by-step with the neural capacity for perceiving the meaning of words and making them up. The process would have grown from grimaces and lip smacking, through mandidular cyclicity, through to the refined speech we have today…

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  4. David Paxton

    Veterinarian

    Thank you for the glimpse of complexity, Andrew. Just when I thought rocket science was the end goal, along comes epigenesis. I wonder if it would be fruitful to look at the uniquely human neurones as word processors? Much of human head anatomy appears evolved for enunciation, so why not some neurone groups as well, especially in the neocortex? I think Naom Chomsky had this insight in referring to an inheritable universal grammar? (He also suggested a mutant gene for language but I think that is too far fetched.) Words are powerful ways of building information and symbols,over and above the mere relaying of emotional states such as alarm or need. Words are computations, so perhaps right in the bailiwick of Computational Biology? Best wishes.

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    1. Kim Peart

      Researcher & Writer

      In reply to David Paxton

      David Paxton ~

      Would Dawkins' meme concept fit the bill ('The Selfish Gene' 1976)?

      As the Universe began as information that gained expression as matter, stars, planets, life and human culture, so the information that we drive feeds back into the shaping of our genes.

      Kim Peart

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  5. Alex Cannara

    logged in via LinkedIn

    And, don't forget the 2-letter genetic 'defect' that allows human forebrains to grow larger in fetal development, because the skull is less constrained by the defect's weakening of jaw muscles.

    The geneticist who discovered this defect via his own saliva DNA testing, at first thought he was defective, until all others he tested showed the same omission of two bases.

    Humans lacking this error suffer micro-cephaly.

    Just in case anyone still believes in evolution moving steadily toward growing human superiority, our brains are also smaller than they used to be..
    ;]

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    1. Roy Niles

      logged in via Facebook

      In reply to Alex Cannara

      Evolution is a trial and error process, where we take intelligent advantage of accidents. Our errors to that extent are sometimes made on purpose.

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    2. Alex Cannara

      logged in via LinkedIn

      In reply to Alex Cannara

      RoyN says:we use "trial and error process, where we take intelligent advantage of accidents"

      Trial & error is by definition, not "intelligence". Iflife did that, it would evole slowly, if at all.

      You must realize that many aspects of our genetics are not inherited as genes, but also 'inherited' as parental modification to the massive control structures that surround and modulate expressions of our genes?

      This means that organisms come prepared for some environmental challenges in ways other than simply DNA codes.

      All that "junk DNA" that was supposed to exist has functions that even span generations. We learned that too, but not by trial & error. Evolution occurs via variation for sure, but variation within definite bounds.

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  6. Dov Henis

    retired industrial consultant, PhD UPgh, PA USA

    Human Intellect Evolution/Devolution

    A. Evolution of Human Intellect!
    All life, all organisms, are evolution products of RNA nucleotide genes, the prime organisms of Earth life.

    The drive/goal of evolution/replication of ALL organisms is natural selection, which is the drive/ goal of every mass format to enhance its constrained energy, to intake energy or its energy be taken in by other mass formats. This drive/goal derives from the on-going expansion of the universe, which is the conversion…

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    1. Roy Niles

      logged in via Facebook

      In reply to Dov Henis

      Intelligence was unintelligently selected, is that it?

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    2. Alex Cannara

      logged in via LinkedIn

      In reply to Dov Henis

      A bit over stated, Dov. And, "the RNA nucleotide genes" is only partly correct -- RNA may well have been an orioguinal genetic substrate, but DNA overtook it in higher organisms for various biochemical reasons. We still use RNA, and many virusses do, but DNA has valuable properties that evolution has indeed preferred.

      By the way, evolution isn't "intelligence" or anything subtle at all -- it's differential reproduction (and death), as Darwin & others knew well.

      Evolution is also fully dependent…

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    3. Roy Niles

      logged in via Facebook

      In reply to Dov Henis

      Alex says "By the way, evolution isn't "intelligence" or anything subtle at all -- it's differential reproduction (and death), as Darwin & others knew well."
      Darwin thought that an animal's "intelligent" reaction to experience drove its evolution, although he seemed to think the forms developed and the functions followed. He was apparently persuaded to change his mind in any case and give all credit to external influences.
      More lately we have discovered that all evolution is driven by the intelligent devices life has found to take advantage of nature's accidents.
      Even though both Dov and Alex seem to be arguing that it is accidents that take advantage of life in that respect - no intelligence needed on either side of the equation..

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    4. Roy Niles

      logged in via Facebook

      In reply to Dov Henis

      Excuse me, I just noted that Dov has amended his dissertation to include intelligence all up and down the line.

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    5. Alex Cannara

      logged in via LinkedIn

      In reply to Dov Henis

      RoyN: "intelligent devices life has found to take advantage of nature's accidents"

      How jas "life found" intelligent devices? Are bacteria "intelligent"? what about virusses -- they exploit bacteria & other cells to do work they can't -- sounds "intelligent", eh?

      What seems to be the problem is that some of us can't ascribe life's properties to anything but some intelligence, grand or not.

      What's wrong with simply admitting we don't know what intelligence is and that Nature has done very well without a definition in evolving all manner of life?

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  7. Roy Niles

    logged in via Facebook

    Alex asks," What's wrong with simply admitting we don't know what intelligence is and that Nature has done very well without a definition in evolving all manner of life?"
    Because all life forms use trial and error intelligence just to live and survive, and to react to what they see as accidents of nature, and to adapt their behaviors to new experiences and evolve. And if you do't know what trial and error intelligence is, look it up. Nature has done nothing very well without it.

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    1. Dov Henis

      retired industrial consultant, PhD UPgh, PA USA

      In reply to Roy Niles

      Decide, Humanity: Scientism Or Natural Selection
      May 19, 2012

      http://www.sciencemag.org/site/special/conflict/index.xhtml http://news.sciencemag.org/sciencenow/2012/05/roots-of-racism.html?ref=em

      Scientism:

      A doctrine and method characteristic of scientists, and the proposition that scientific doctrine and methods of studying natural sciences should be used in all areas of investigation and in conduct of politics-social-cultural-civil affairs in pursuit of an efficient practical, as…

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  8. Roy Niles

    logged in via Facebook

    Alex says, "Trial & error is by definition, not "intelligence". Iflife did that, it would evole slowly, if at all."

    How would you use trial and error without intelligence? And how does your natural selection process work with no intelligent input from the organism that the accidentally or otherwise selected traits were supposedly selected to fit? And how does life evolve more quickly accidentally than it would if it had some choices to make in the process? And how do any of your unintelligent life forms make choices without any form of decisive analysis involved?
    I don't really care if you want to believe bacteria, viruses etc. have no processes or functions that require some intelligence to use. I just like to see how people like you answer these questions.

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      "How would you use trial and error without intelligence?" -- 1st off, define "intelligence".

      2nd, do you realize how maany deaths/failures to reproduce are involved in each evolutionary step that's sugject to selection?

      Evolutionary "trial and error" is mostly error.

      The same is true for artificial selection used in computing systems to design other systems. The Sony effort to have artificial selection revise how its robot toy dog walked yielded very many 'dogs' that wouldn't 'hunt'.

      The same is true in the real world of nature. One doesn't need intelligence internal to evolution's processes.True intelligence would design the next 'improved' organism without delay & waste of selectively failed versions.

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    2. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex says: "1st off, define "intelligence"."

      intelligence |inˈtelijəns|
      noun
      1 the ability to acquire and apply knowledge and skills

      All life forms have some knowledge of what they need to do to survive, and all of them have acquired in one way or another the skills to try and occasionally succeed in doing so.

      And to say that trial and error is mostly error does not change the fact that it's an intelligent and effective process, because everything we try has less than perfect results. Nothing is so intelligent that it makes no errors; if it were, it would have no need to learn and no need or reason to evolve.

      Alex also says: "True intelligence would design the next 'improved' organism without delay & waste of selectively failed versions."
      Unfortunately we have no evidence that such a perfect form of errorless intelligence yet exists, so that's a useless argument.

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    3. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      So Roy, do you see your conflation of trial & error with intelligence makes no sense?

      "the ability to acquire and apply knowledge and skills" doesn't say anything about how to attain "knowledge" or "skills".

      "Trial & error" would be listed as an intelligent act, if true. But it's not. Tiral & error requires no intelligence, just the ability to sense an error and make some new try, perhaps randomly.

      WWII buzz bombs did that, using very basic inertial course sensing and extremely rudimentary course correction system (repeatedly flipping a rudder one way or the other).

      Intelligence? Well, more "intelligent than trying to find England randomly after launch.
      ;]

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    4. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Forgot this, Roy: "we have no evidence that such a perfect form of errorless intelligence yet exists"

      Never said intelligent decision making is errorless, it simply makes use of available information and knowledge. Trial & error doesn't do that.

      Organisms, even you or I, aren't conscious of what mutations in our genetics may have occurred and what their effects are. Nor is Nature overseeing us individually.

      Selection under serious mutation mostly results in individual death or failure to reproduce. In any case, the organism and its genes aren't making "trial & error" decisions.

      Do you know which of the typically 2 germ-line mutations per year you've accumulated in 2012? Do you know what their effect(s) might be? Is some "intelligence" directing what happened and what the "error" will be of your 2012 "trial", whatever that is?

      Where is the "intelligence?"

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  9. Roy Niles

    logged in via Facebook

    @Alex,
    "Trial & error" would be listed as an intelligent act, if true. But it's not. Tiral & error requires no intelligence, just the ability to sense an error and make some new try, perhaps randomly."

    You've just argued that intelligence at minimum is unintelligent. Hopeless.
    Go google the concept and perhaps you'll learn what trial and error means to the rest of us.
    Or perhaps not.

    Here's the best one yet from Alex:
    "Do you know which of the typically 2 germ-line mutations per year you've accumulated in 2012? Do you know what their effect(s) might be? Is some "intelligence" directing what happened and what the "error" will be of your 2012 "trial", whatever that is?"

    Are those germ-line mutations accidentally intelligent? Or does my body have to address their effects intelligently? Or does it all happen automatically like your intelligently constructed by the Nazi's buzz bomb example? Is natural selection run by some natural evil dictator then?
    Wow.

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      It seems you don't actually understand the definition you looked up, Roy...

      "the ability to acquire and apply knowledge and skills"

      Do you know what "knowledge" means and requires? Do you know what "apply" means & requires?

      Apparently, not.

      Watch those mutations you got this past year, Roy!
      ;]

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    2. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex, There are books and papers written up the scientific gazoo by biologists and other evolutionary scientists who have convinced even neo-Darwiniists that life forms from microbes on up the various trees of life have at least a minimum of intelligence, define it any way you like.
      Your arguments that life doesn't need it to start with are simply silly. Your further arguments that life didn't acquire intelligence until much later in the game with, per your example, animals that were much closer…

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    3. Dov Henis

      retired industrial consultant, PhD UPgh, PA USA

      In reply to Roy Niles

      Re evolution and intelligence

      Humans are constituents of Life.
      Life is simply another mass format, derived from naturally selected RNA nucleotides.
      All mass formats derive from gravitons, the fundamental universe particles.
      All mass formats are presently reconverting to energy, to gravitons/mass-formats in motion.
      Intelligence is enhancing, based on experience, the energy constraint, for postponing this reconversion as long as possible.
      See black holes and life…

      Suggesting,

      Dov Henis (comments from 22nd century)
      http://universe-life.com/

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    4. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Roy, Roy, Roy -- "life forms from microbes on up the various trees of life have at least a minimum of intelligence, define it any way you like"

      Ok, I define it as not what our dictionaries define "intelligence".

      Now how far, pray tell us, do we go down below bacteria to exit your "intelligent life"? Are virusses "intelligent"? They operate very effectively by co-opting other entities with reproductive abilities they lack.

      So, Roy, are virusses "intelligent".

      The definition includes…

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  10. Roy Niles

    logged in via Facebook

    Alex, I wanted you to have the last word, but then you had to ask a series of foolish questions. Of course viruses have intelligence. By your own reckoning they have strategies that require trial and error choice making. They are notorious for learning from experience and adapting to defeat our new defenses.
    Do life's cells have intelligence? Well, they certainly are required to make informed choices from several possible options. Read Wetware: A Computer in Every Living Cell, by Dennis Bray…

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      So Roy, explain how virusses are intelligent, but the molecules that fold just right to serve all sorts of purposes aren't.

      What you seem unable to realize is that your definition of "life" and intelligence" are the same.

      You make no distinction, and distinctions are key to learning, and to...

      "the ability to acquire and apply knowledge and skills"

      -- what you provided as the definition of "intelligence". So you conflate the definitions of both "life" and "intelligence".

      Why two distinct words, then, Roy?

      Doesn't sound intelligent. But, they way you proceed is indeed "trial & error". You just don't seem to see the "error" part.
      ;]

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  11. Kim Peart

    Researcher & Writer

    The best tackle of the conundrum being broached here in recent comments lies in an appreciation of the primal cause of existence.

    For those accepting the Big Bang, there is the interesting situation that the cosmos begins as a singularity, an event which marks the boundary of information and therefore, our ability to apply science to any problem transcendent of the cosmos.

    This is because science is built on the interpretation of the information found in the Universe and we are being told that…

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    1. Roy Niles

      logged in via Facebook

      In reply to Kim Peart

      @Kim,
      "If we accept that intelligence is the child of information via the evolution of life, then we don't need to think beyond that, but our conversation will remain puzzled by missing appreciations."

      How did life intelligently use that information to develop intelligence that it supposedly, by your reckoning, didn't have to start with? That's the question that your proposal doesn't answer.

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    2. Alex Cannara

      logged in via LinkedIn

      In reply to Kim Peart

      Kim, you miss that science only has knowledge of what appeared about 1 microsecond after the so-called Big Bang began.

      There's no "singularity" proof, or any other conclusion, that can be made prior to our best knowledge of that microsecond..

      There are, in fact, many theories that require no "singularity", no matter how appealing that word may be to readers of books hawked by science writers.

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    3. Kim Peart

      Researcher & Writer

      In reply to Kim Peart

      Roy Niles ~

      Did life "intelligently" use cosmic information?

      When we consider the birth of the cosmos, what state of being is driving all that is happening with expansion and matter, that opens the way for stars, planets, life and the machine makers.

      I am suggesting that "intelligence" is the wrong term to apply to the functioning of natural law as expressed in matter and life.

      I am suggesting that there is a higher state that transcends the cosmos and drives it.

      Rather than "intelligence…

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    4. Kim Peart

      Researcher & Writer

      In reply to Kim Peart

      Alex Cannara ~

      Read again and you will see that is exactly what I am saying, that "science only has knowledge of what appeared about 1 microsecond after the so-called Big Bang began."

      I am keen to know what is really going on in the cosmos.

      Theories will whiplash all over the place.

      Hubble did well to see that the Universe was expanding.

      Views on cosmic origins are now drawn from a reverse of this expansion.

      Through science we have discovered reality, but reality is also greater than science.

      Kim Peart

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  12. Roy Niles

    logged in via Facebook

    @Alex, "So Roy, explain how virusses are intelligent, but the molecules that fold just right to serve all sorts of purposes aren't."
    The molecules are folded intelligently by choices made and determined from the experiences of the life forms these complex molecules serve.
    The silliness of that question is evidence that you have no evidence to argue your case with at all. Did you presume that molecules have to fold just right, but serve all sorts of purposes, yet fold the same way every time; or if not, fold differently by pure accident? Or do they fold by the intelligence somewhere outside of their forms, which you've already denied exists?

    Please stop asking silly questions so I won't have to ask you why you asked them in return.

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Roy, it's now clear you have no biochemistry knowledge. Nor do you seem to have any scientific knowledge, when you say oddly meaningless things like...

      "Did you presume that molecules have to fold just right, but serve all sorts of purposes, yet fold the same way every time; or if not, fold differently by pure accident? Or do they fold by the intelligence somewhere outside of their forms"

      When you do learn some biochemistry and biology, write back.
      ;]

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    2. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      "Did you presume that molecules have to fold just right, but serve all sorts of purposes, yet fold the same way every time; or if not, fold differently by pure accident? Or do they fold by the intelligence somewhere outside of their forms"

      Alex, I obviously know much more abut biology as well as biochemistry than you do, since you can't answer that simple question at all. Frankly, I don't know of any biologists that can't. (Biochemists are sometimes a different story.)
      But then I don't know that you have any scientific education at all for that matter.

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    3. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Well, Roy, we can play count science degrees if you like, but your question/statement:

      "The molecules are folded intelligently by choices made and determined from the experiences of the life forms these complex molecules serve. "

      Appears to have made you overconfident, despite its being meaningless. Proteins fold because of how their peptide constituent molecules relate chemically with one another,, as the protein forms from DNA transcription.

      Outside molecules may well attach and modify…

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    4. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex answered: "The 'choices' made by the evolution of a protein, like hemoglobin, were made by evolution through selection over many generations. No organism made any "choice" in the matter."

      I knew that would be your answer, straight out of the neoDarwinist books. Which gave never even tried to explain how things are made by evolution but no choices are involved by anything, and especially not by the organisms.
      All of this extremely complicated process evolved by accident, is that your answer…

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    5. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Finally your religious, unscientific belief shows, Roy!

      " the ability to acquire and apply knowledge and skills" -- "intelligence", remember?

      "fitness involves no form of trial by the organism?" -- your last question.

      So a bower bird built the 1st bower to lure a mate by trial? Or a heme group first folded from mutated-DNA peptide concatenation because the organism was "trying" something?

      You reveal a profound belief that exposes a profound lack of biological, chemical and genetic knowledge…

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  13. Roy Niles

    logged in via Facebook

    To Kim Pearl: You stste:
    "Rather than "intelligence", I suggest that the transcendent state of being is a better candidate to blame for the cosmic dance that we marvel at. When we accept the simple observation that natural law was in full working order at the dawn of time, then we are confounded with a puzzle, that the Universe is exceptionally detailed at its birth and all that happens subsequently is an expression of natural law"
    Lawrence Krauss has conceded that physical laws were already in…

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    1. Kim Peart

      Researcher & Writer

      In reply to Roy Niles

      Roy Niles ~

      There is that interesting detail that space and time stretched from the beginning, giving us the space-time continuum in which we dwell.

      Being stretched, there is a primary oneness of space and time.

      Being a stretched oneness, there is essentially no separation of any space or time in a higher order of existence.

      How best to describe the dynamic of the cosmic driver that delivers up ever increasing levels of diversity?

      Using the term intelligence, there is a risk of implying…

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  14. Roy Niles

    logged in via Facebook

    Kim, you say, "Using the term intelligence, there is a risk of implying "intelligent design" which is essentially creationism in a world with a Biblical overlord."
    Well, I see that as the creationist's and the neo-Darwinian's problems and not mine. You are welcome to postulate a new term for a higher intelligence, but if you do away with the intelligence aspect, you have no other explanation for the increase in its functionality.

    And you say, "Short of working evidence of a divinity moving the cosmic chess pieces, we still have the conundrum of the dynamic of natural law driving amazing outcomes through all of time."
    Well we certainly don't know the nature of the self evolving strategies that universal systems must, in my view, depend on, but we must assume that some form of strategic intelligence has always existed, simply because we can't, with any of our logical acumen to date, assume the opposite.

    But good luck in developing your theory in any case. It's never easy.

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    1. Kim Peart

      Researcher & Writer

      In reply to Roy Niles

      I wouldn't say that this is a theory, but a question that has been muddled upon for millennia in some parts.

      I suggest that the term "intelligence" cannot address what is happening, especially as intelligence is more about the human experience and to project our small mind onto the function of the transcendent multiverse may simple be throwing up a smoke screen that hides a better view of reality.

      This is where I prefer a term like transcendence, to refer to a state of being with a multiverse that is infinitely greater than the cosmos and which also works through the cosmos to animate the mysteries of life.

      Whatever we are dealing with, for us it is a mystery, but a mystery that we are intimately connected with and which is the font of our intelligence.

      Kim Peart

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  15. Roy Niles

    logged in via Facebook

    Alex, here's one of the the best examples of the ignorance, and your arguments from such, that you seem inordinately proud of:
    "By the way, here's something for your equivalence of "trial & error" with "intelligence" -- methane molecules (CH4) are produced by living organisms, so represent an intention of those organisms' metabolisms to do so. Because of its biological origin, each CH4 'knows' (your theory) where it came from, and it 'knows' that the organism was either a photosynthesizer or Oxygen…

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Roy, it takes $25 and 7 people who agree to meet once a week, to start a religion in Calif. How about checking your local govt? You already have as incomprehensible a liturgy as any established religion!

      By the way, remember over a day ago, when you wanted me to "have the last word"? Let's try that on for size, to spare others, eh?.
      ;]

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  16. Roy Niles

    logged in via Facebook

    Alex, you should have taken the last word without a question when you had the chance. As to a religion, you clearly haven't noticed that I'm preaching the gospel of the adaptive mutationists, and I could name about twenty of them in high academic places if you like. One or two of them believe in a god, and some of them are in Australia, but then nobody's perfect.

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Not a man of your word, eh Roy? Are you really a Slitherin?
      ;]

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    2. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex, It was supposed to be a last word, not a last insulting question. Go read up on adaptive mutation if you can. The level of abstract thought involved is a bit high for those who have your problems with the concept of intelligence.

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    3. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      I understand "adaptive mutation", Roy. It's not "intelligence" as in the dictionary you quoted.

      You really are ready to lead a religion, or cult, Roy...

      "It was supposed to be a last word, not a last insulting question"

      Check how much it costs over there.
      ;]

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    4. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex, now you're simply lying, although of course you haven't known what intelligence is to begin with. Check this from Mae-Wan Ho, Geneticist and Biophysicist, excerpted from The End of Bad Science and Beginning Again with Life:
      “Finally, the ultimate neo-Darwinian taboo has been broken. Wiesmann’s barrier has been breached, and in many different forms, some of which I mentioned already (see box 2).
      Box 2:
      The inheritance of acquired characters
      Epigenetic inheritance - inheritance of cellular…

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    5. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      "Alex, now you're simply lying" -- Roy, don't you get that when polemics are the resort, your argument is lost?

      Really, don't pass up the opportunity to see what it takes there to set up a religion -- you're obviously qualified to lead folks willing to drink the Koolaid you brew,
      ;]
      And, when you get some time, have a sit down talk with your 10 trillion or so cells and try to find out why their adaptive "choices" took so long -- several millions of years -- to reach the intellect you have. They really should be castigated for their laziness in making past choices to influence your "intelligence".
      ;]

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  17. Roy Niles

    logged in via Facebook

    Alex, now you've been reduced to simply babbling. Of course adaptive choices took those those millions of years. And 10 billion or so cells barely touches the amount that had to have been involved. And doing all of that work stochastically defies any and all explanations. Repeating the dogma as you do won't qualify as an explanation of anything.
    And it's nice that you keep giving me credit for the adaptive mutation theories. Really now, I don't deserve it.
    James Shapiro did a little bit to help me when he wrote it up.

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    1. Alex Cannara

      logged in via LinkedIn

      In reply to Roy Niles

      Roy, you shortchange both yourself -- ~10 trillion cells -- and the ability you claim they have for choice.

      But do get the paperwork going for your religion/cult!
      ;]

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    2. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex,
      Again in your babbling you give me too much credit for the evolving nature of our evolutionary philosophies. And I haven't even told you about the most interesting new parts. They involve the function that you claim you've never had, or if you've had, you've never used.

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    3. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex,
      You're just a foil that helps us spread the word. is that a problem for you?

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    4. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Apex, does that mean that you're giving up the mother nature myth?

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    5. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Alex, Oops I called you apex. You don't really have a pointy head, or do you?

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    6. Alex Cannara

      logged in via Facebook

      In reply to Roy Niles

      Keep pumping it out, Roy. You may hook someone wyet, with your misinterpretation of Shapiro, etc!

      Remember, get those papers started for your new religion!

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    7. Roy Niles

      logged in via Facebook

      In reply to Roy Niles

      Did someone who's afraid to criticize Shapiro just say that I had misinterpreted him? How did I misinterpret a direct quote? He couldn't say. But in a way, this person is recommending that Shapiro's book be read, apparently because it somehow disproves my points and proves his.
      And that's fine with me, because if you read it, you'll learn something either way.

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  18. Yoron Hamber

    Thinking

    Very interesting read. And it seems a very complex new field of study.

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    1. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      Careful when you read Niles' stuff, Yoron, epi-genetics and the influences of parent's extra-genetic systems on offspring & their gene expression is indeed known to exist, and is a very important research topic.

      Niles, however, is not about the science.
      ;]

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    2. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, Alex knows adaptive mutation is not simply epigenetics that's replacing the older neoDarwinian version of stochasticism. He doesn't seem to have the knowledge to honestly defend the system that he's been somehow indoctrinated with.

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    3. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      And, Yoron, notice how carefully Roy evades the full content of what I said, and focuses on just "epi-genetics". Remember, Roy is no scientist, though he tries to fake it with big fluggy words.

      Good try, Roy.
      ;]

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    4. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, Alex is babbling again so he won't have to admit he has no knowledge at all about the latest discoveries in evolutionary science. He's not a scientist OR a philosopher, or even a good student of the subject. He has no authorities to cite who can counter the authoritative texts that I've cited. He simply cannot argue honestly, so resorts to deceptive commentary and accuses others of the same tactics as part of his shtick. Pitiful.
      A very good book to read on the subject is here:
      Evolution: A View from the 21st Century (FT Press Science) [Kindle Edition]
      James A. Shapiro

      You won't have to wade through Alex and his drivel in the bargain. He's been afraid to talk about it.

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    5. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      Ah, Yoron, see how easily Roy traps himself? He's no idea you & I have known of each other and discussed various issues in science.

      Keep trying, Roy!

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    6. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, if you know Alex, all the better. Maybe you can let him borrow Shapiro's book.

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    7. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, here's the 1st reviewer for the Shapiro book...

      "Genomes, it seems, are built to evolve ---not at the petty pace of classical genetics, but in leaps that entail rearrangement of the genetic architecture or the import of foreign information...The central question for me turns on that supple word, "random", which commonly means precisely what the user wants it to mean. When cells sense danger, they restructure their genome by natural genetic engineering; but the variations so generated are…

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    8. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, I've actually read the book and have actually quoted Shapiro's writing on its subject here.
      Alex has cherry picked a review because he's afraid to quote Shaipiro and disagree with what he actually said. He can't protect himself from revealing his ignorance if he does that. He's stuck with what he's written here so profusely and can't let his associates see the evidence of how wrong he's been. This is of course what dishonest people do when they're caught pretending to know something that they don't.
      So I suggest again that you read the book, and not a review that may or may not have found it to their liking Lots of reviewers have had a problem with the stuff that disagrees with Dawkins, for example.
      But that's science and I invite you to make up your own mind. Read the scientist, and ignore the arguments between the non-scientists about what that scientist says. And especially ignore the dishonest attempts to divert you from reading these books at all.

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    9. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      Roy, unfortunately, is emotionally involved, so makes false statements about what Shapiro wrote. Shapiro does not say what Roy says about our genetic structures making "intelligent decisions".

      But Roy has another agenda than fact.

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    10. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, read the book and find out what Shapiro says, not what Alex so desperately says he doesn't say. While you're at it, read this easy to download paper by Shapiro:

      James A. Shapiro, Department of Biochemistry and Molecular Biology,
      University of Chicago:
      Bacteria are small but not stupid: Cognition, natural genetic engineering, and sociobacteriology.
      http://shapiro.bsd.uchicago.edu/2006.ExeterMeeting.pdf

      Shapiro also wrote this: “The realization that most DNA changes in bacteria…

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    11. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, if you completely trust Alex in return, perhaps you should skip the book. But everyone else that may be still reading this should give it a good look.

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    12. Alex Cannara

      logged in via Facebook

      In reply to Yoron Hamber

      From Roy, desperately: "Yoron, if you completely trust Alex in return, perhaps you should skip the book. But everyone else that may be still reading this should give it a good look"

      Poor Roy, "still blabbering away. It's not working for him." -- who said that?
      ;]

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    13. Roy Niles

      logged in via Facebook

      In reply to Yoron Hamber

      Yoron, Don't you hate it when someone says LMAO. But that last non sequitur from Alex was a gooser. Anyway the data from the scientists, James Shapiro and also Mae-Wan Ho, have been presented here for anyone who is interested to follow up on. Stuff you'll note that Alex has studiously pretended wasn't there to read. He really is afraid that the mistakes he has repeatedly made here will be hard to erase if Shapiro's very professional work is recognized by readers for what it is. Note that he…

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