The way melanoma cells manage tangled DNA could explain why they rapidly develop resistance to cancer treatment.
Researchers at the University of Queensland Diamantina Institute have identified a cellular “checkpoint” that detangles DNA during melanoma cell division. When broken down, this checkpoint facilitates resistance by “over-activating” an important cell survival pathway.
Researchers now want to investigate precisely how the checkpoint defect over-activates this pathway, known as PI3K. This could lead to new therapeutic targets being identified.
Read more at University of Queensland Diamantina Institute