Mechanism for chemotherapy resistance by melanoma

The way melanoma cells manage tangled DNA could explain why they rapidly develop resistance to cancer treatment.

Researchers at the University of Queensland Diamantina Institute have identified a cellular “checkpoint” that detangles DNA during melanoma cell division. When broken down, this checkpoint facilitates resistance by “over-activating” an important cell survival pathway.

Researchers now want to investigate precisely how the checkpoint defect over-activates this pathway, known as PI3K. This could lead to new therapeutic targets being identified.

Read more at University of Queensland Diamantina Institute