Nicotine primes brain for cocaine use – now we know how

Cigarettes and alcohol serve as gateway drugs, which people use before progressing to the use of marijuana and then to cocaine and other illicit substances. Researchers have now provided the first molecular explanation for the gateway sequence. They show that nicotine causes specific changes in the brain that make it more vulnerable to cocaine addiction – a discovery made by using a novel mouse model.

Read more at Columbia University's Mailman School of Public Health