New repository explores genetic influence on metabolism

Researchers in the UK have created an atlas of genetic associations with metabolic molecules, providing new insights into how genetic variants influence complex disease and drug response in the body.

The team from the Wellcome Trust Sanger Institute linked 145 genetic regions with over 400 molecules involved in human metabolism, and found 90 new genetic associations, trebling the figure of known associations with metabolic pathways.

Senior author Nicole Soranzo said researchers could use this new compendium of knowledge to assess genetic influences in drug-development programs and conditions, such as hypertension, diabetes and cardiovascular disease