Cathryn Nagler

Ongoing work in our laboratory explores the cellular and molecular interactions by which commensal bacteria regulate sensitization to food allergens. Oral and subcutaneous allergen-specific desensitization protocols are already showing promise for treating food allergy. Our data suggest that pairing Clostridia enrichment of the gut microbiota with these tolerance inducing protocols may potentiate antigen specific tolerance to prevent or treat food allergy. We will partner with a biotech company to translate our mouse model findings to novel adjunctive probiotic therapies for patients with food allergy.