I am the Head of the Department of Psychiatry at the University of Melbourne and a psychiatrist at the Royal Melbourne Hospital. I am the current editor-in-chief of the Australian and New Zealand Journal of Psychiatry. My main clinical and research interest is in the management of severe mood disorders. I have led, or am leading, large multicentre clinical trials of treatments for depression examining psychotherapy, antidepressant medications, anti-inflammatory agents, and ketamine. I am also interested in using brain imaging to better understand depression and social-affective processes.