Dr Little commenced at the University of Sydney based at the Children’s Hospital, Westmead, when it opened in November 1995. In 1998 he began researching the role of bisphosphonates in distraction osteogenesis and in 1999 officially founded Orthopaedic Research and Biotechnology at CHW, which he heads.
In 2005 Dr Little was awarded his PhD on bisphosphonates in distraction osteogenesis. He has initiated further research on osteonecrosis, fracture healing and the interaction of the anabolic and catabolic responses in bone repair. Current focuses include improving bone healing outcomes in neurofibromatosis, and using muscle for in vivo bone tissue engineering. Dr Little remains active clinically and is now working on translating pre-clinical work on bone repair to clinical practice.