Chief Executive Officer, Australian Phenomics Network; Manager, National Centre for Indigenous Genomics, Australian National University

Michael Dobbie is the Chief Executive Officer of the Australian Phenomics Network, based at the Australian Phenomics Facility on the campus of The Australian National University (ANU), Canberra, Australia. After gaining biomedical science degrees in Sydney, Michael extended his research training in London and Oxford, UK, where he completed his PhD and two postdoctoral projects before he fully realized the utility of the mouse to annotate the genome and make new links between genes and disease. He has spent the last seven years as a research manager at ANU developing new projects to capitalize on the power of the phenomics approach to serve medical researchers worldwide.

Michael enables the application of functional genomics and phenomics approaches to better understand gene function and the genetic causes of disease. Medical research fields Michael has directly contributed to include: genetics, vascular biology, the blood-brain barrier, neuroscience, cancer angiogenesis, metabolism, developmental biology, malaria, and oxidative stress.

The Australian Phenomics Facility is the lead organisation of the Australian Phenomics Network, which is Australian Commonwealth government-funded (National Collaborative Research Infrastructure Strategy, Education Investment Fund, Collaborative Research Infrastructure Scheme) to provide the infrastructure and services to create, characterise and bank new models of human disease.

Michael is also the Manager of the National Centre for Indigenous Genomics (NCIG) at the Australian National University. NCIG brings together the oldest living culture with the newest science by establishing a national resource, under Indigenous governance, for appropriate and respectful genetic and genomic research that will benefit Indigenous Australians. An introductory animated video can be found at http://ncig.anu.edu.au/

Experience

  • 2013–present
    Chief Executive Officer, Australian Phenomics Network, The Australian National University
  • 2014–present
    Manager, National Centre for Indigenous Genomics, The Australian National University
  • 2006–2014
    Scientific Business Manager, Australian Phenomics Facility, The Australian National University
  • 2012–2013
    Chief Operating Officer, Australian Phenomics Network, The Australian National University
  • 2003–2006
    Postdoctoral Translational Research Fellow, Cancer Research UK

Education

  • 2001 
    University of London, PhD
  • 1994 
    University of Sydney, MSc
  • 1985 
    University of Technology, Sydney, BAppSc (Biomed Sc)

Publications

  • 2013
    Genome-Wide ENU Mutagenesis in Combination with High Density SNP Analysis and Exome Sequencing Provides Rapid Identification of Novel Mouse Models of Developmental Disease, PLoS One
  • 2011
    ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice, Journal of Biomedicine and Biotechnology
  • 2006
    Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer, Clinical Cancer Research
  • 2003
    Nitric oxide and peroxynitrite cause irreversible increases in the K(m) for oxygen of mitochondrial cytochrome oxidase: in vitro and in vivo studies, Biochim Biophy Acta
  • 2003
    Interaction between flavonoids and the blood-brain barrier: in vitro studies, Journal of Neurochemistry
  • 2002
    Drug resistance in epilepsy: the role of the blood-brain barrier, Novartis Foundation Symposiums
  • 2001
    A comparison of the induction of immortalized endothelial cell impermeability by astrocytes, Neuroreport
  • 1999
    Upregulation of intercellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor-alpha in an in vitro model of the blood-brain barrier, Brain Research
  • 1998
    An immortalized in vitro model of the blood-brain barrier: glutathione levels and sensitivity to oxidative stress, Biochemical Society Transactions
  • 1998
    Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood-brain barrier model system, Brain Research
  • 1997
    Concentrations of quinolinic acid in cerebrospinal fluid measured by gas chromatography and electron-impact ionisation mass spectrometry. Age-related changes in a paediatric reference population, Journal of Chromatography Part B Biomedical Science Applications
  • 1996
    Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate, Journal of Applied Toxicology
  • 1991
    The male antifertility activity of 6-chloro-6-deoxyglucose, Contraception
  • 1988
    Is the nephrotoxicity of (R)-3-chlorolactate in the rat caused by 3-chloropyruvate?, Xenobiotica

Professional Memberships

  • Australia and New Zealand Society for Cell and Developmental Biology

Research Areas

  • Medical And Health Sciences (11)
  • Genetics (0604)
  • Genomics (060408)
  • Medical Genetics (Excl. Cancer Genetics) (110311)
  • Cancer Genetics (111203)