Senior Lecturer in Pharmaceutics, University of Sydney

Dr Wheate completed a Bachelor of Science degree with 1st class honours from the University of New South Wales whilst at the Australian Defence Force Academy. He then completed a PhD in medicinal chemistry under Professor J. Grant Collins. Since then he has worked in the School of Biomedical and Health Sciences at the University of Western Sydney (Australia) and the Strathclyde Institute of Pharmacy and Biomedical Science (Scotland) before taking up a position in the Faculty of Pharmacy at the University of Sydney (Australia) in 2012.

Dr Wheate's research interests lie in whole-of-pipeline discovery and development of platinum-based anticancer drugs including: design and synthesis, in vitro and in vivo screening, drug-DNA binding, nanoparticle based delivery, solid state chemistry and co-crystals, toxicology and pharmacokinetics, and dosage formulation. Additionally, his research also examines the drug delivery application of macrocycles (including cyclodextrins, cucurbiturils and pillararenes) and their host-guest complexes.

Dr Wheate was previously the Head of Cancer Research in the Faculty of Pharmacy.

Experience

  • 2012–present
    Senior lecturer in pharmaceutical science, University of Sydney
  • 2007–2012
    Lecturer, University of Strathclyde
  • 2005–2007
    Senior Research Fellow, University of Western Sydney
  • 2001–2002
    Associate Lecturer, University of New South Wales

Education

  • 2002 
    University of New South Wales, PhD

Publications

  • 2015
    Cucurbit[7]uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model, Journal of Ovarian Research
  • 2015
    The state-of-play- and future of platinum drugs, Endocrine-Related Cancer
  • 2014
    Topical Cream-Based Dosage Forms of the Macrocyclic Drug Delivery Vehicle Cucurbit[6]uril, PLoS One
  • 2014
    Analysis of montmorillonite clay as a vehicle in platinum anticancer drug delivery, Inorganica Chimica Acta
  • 2014
    A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol, Journal of Inorganic Biochemistry
  • 2014
    Chemical factors affecting cucurbit[n]uril formulation into ocular dosage forms: excipient binding, solubility, corneal permeability and antibiotic encapsulation, Supramolecular Chemistry
  • 2014
    The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles, Toxicology Research
  • 2014
    Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents, Journal of Visualized Experiments
  • 2013
    Evidence for a Role of Executive Functions in Learning Biology, Infant and Child Development
  • 2013
    Platinum anticancer drugs, Encyclopedia of Metalloproteins
  • 2013
    DNA-based aptamer fails as a simultaneous cancer targeting agent and drug delivery vehicle for a phenanthroline-based platinum(II) complex, Journal of Inorganic Biochemistry
  • 2012
    Magnetised Thermo Responsive Lipid Vehicles for Targeted and Controlled Lung Drug Delivery, Pharmaceutical Research
  • 2012
    Cisplatin-Tethered Gold Nanoparticles That Exhibit Enhanced Reproducibility, Drug Loading, and Stability: a Step Closer to Pharmaceutical Approval?, Inorganic Chemistry
  • 2012
    Rationalising sequence selection by ligand assemblies in the DNA minor groove: the case for thiazotropsin A, Chemical Science
  • 2012
    Nanoparticles: the future for platinum drugs or a research red herring?, Nanomedicine
  • 2012
    Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields, Inorganica Chimica Acta
  • 2012
    Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity, Dalton Transactions
  • 2012
    Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect, Metallomics
  • 2012
    Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene, Inorganica Chimica Acta

Professional Memberships

  • Fellow and Chartered Chemist of the Royal Australian Chemical Institute

Research Areas

  • Pharmacology And Pharmaceutical Sciences (1115)
  • Medicinal And Biomolecular Chemistry (0304)
  • Physical Chemistry (Incl. Structural) (0306)

Honours

Australian Defence Medal