In October 1964, the University of Malawi was founded. Teaching started in September 1965 at the newly established campus which was formerly an Asian Secondary School in Blantyre. Only 90 students were enrolled. By 1967, the Institute of Public Administration at Mpemba, the Soche Hill College of Education, the Polytechnic, all in Blantyre, as well as Bunda College in Lilongwe, were incorporated as constituent colleges of the University of Malawi.
Except Bunda College and the Polytechnic, the other colleges moved to Zomba in 1973 to form the now Chancellor College campus.Kamuzu College of Nursing became the fourth constituent college in September 1979 and the College of Medicine in Blantyre became the fifth constituent college when it was established in 1991. Currently 7, 371 students are enrolled in various degree, diploma and certificate programmes.