My research team aims to understand how the many diverse types of white blood cells develop, and how constant numbers of these cells are maintained throughout our life. We strive to comprehend how certain genes and tissue environments:
Instruct the development of white blood cells.
Maintain the numbers of different types of white blood cells.
Prime the protective functions of white blood cells.
This knowledge is critical for understanding errors in white blood cell development that are associated with leukaemia and immunodeficiency. Our goal is to contribute to the design of therapies to modulate the activity of white blood cells in chronic infections and cancer.