Professor Barry Mendelow is internationally known for his work in haematology.
In the early 1980s he was the head of pathology at Baragwanath Hospital before taking over as head of department of haematology at Wits University.
He has also been the assistant dean of research at Wits' Faculty of Health Sciences as well as the executive director of research for the university. Later he was also appointed as research manager of the South African Institute for Medical Research.
He is the founding professor and head of molecular medicine and haematology at the university. Professor Mendelow was also the president of the South African Society of Haematology and the president of the Federation of South African Societies of Pathology.
His main research activities have included haematological malignancies (1980-1990), with special reference to genetics of leukaemias (postdoctoral studies under Prof Leo Sachs at the Weizmann Institute, (1980) , pharmacological inhibition of tyrosine kinases (1990-1995) and cell signaling abnormalities in AIDS (1995-2010).
He is a trustee of the Friedland Fellowship.