The Weimer MicroLab focuses on systems biology of bacterial pathogens and host/microbe interactions. We do this by integrating multiple "-omics" technologies in various biological systems ranging from the environment to stem cells to food. Our group is focused on the survival of pathogens in the environment and host and defining how bacteria persist, associate, and alter their environment, especially during nutrient starvation and non-culturability that leads to novel metabolic and host association conditions. The lab is focused on the initial steps of host association and the genomic requirements that impact chronic conditions, particularly chronic inflammation due to organisms transmitted in the food supply that establish long-term associations in the microbiome. These programs are fueled by large-scale whole-genome sequencing in Genomes4Health
To support these efforts out group has an active program rapid molecular detection systems for bacteria and their products from food and the environment that includes capture/concentration strategies as well as metaRNAseq approaches that are coupled to metabolomics to define metabolic changes. This program leverages genomic information to determine robust biomarkers and traits that can be diagnostic for microbes.