Since 2001, I have been involved in bioengineering research centered on creating patient-based computational models of the respiratory system. My initial work focused on developing models of the pulmonary circulation, and these models have been applied to investigate perfusion distribution and gas exchange during pulmonary embolism and to understand the limitations in magnetic resonance imaging (MRI) of pulmonary perfusion. More recently, my research has turned towards simulation of aspects of ventilation and forced expiration with particular application to understanding links between structure-function changes in the obstructive lung diseases of asthma and chronic obstructive pulmonary disease (COPD). My ongoing research goal is to develop efficient novel computational tools - combining mathematical and computational techniques with experimental, imaging and clinical studies - to provide an increased understanding of the pathophysiological mechanisms occurring in obstructive lung and pulmonary vascular diseases. My passion is for the application and translation of computational and image processing techniques to the clinical environment.