Dr Toshner undertook a British Heart Foundation Research Training Fellowship in Cambridge in 2007 where he trained in cell and molecular mechanisms of endothelial dysfunction in pulmonary hypertension. He was appointed to a Wellcome/ NIHR Clinical Lecturer in 2010. He is the current University Lecturer in Translational Respiratory Research and his group is interested in translational and experimental research in pulmonary vascular diseases. He is currently the Chief-Investigator of the Transform-UK trial, the first investigator-led multicentre trial to involve all 7 specialist centres in the UK. He is leading an international genotyping/ phenotyping collaboration in chronic thromboembolic pulmonary hypertension and has close ties to the Pulmonary Vascular Diseases Unit in Royal Papworth Hospital. His research group is focused on preclinical target identification and early phase trials in pulmonary vascular diseases.
The major themes of the group are-
Genetic susceptibility to pulmonary hypertension
The pathobiology of chronic thromboembolic pulmonary hypertension
Novel early phase drug development in pulmonary hypertension