Sara Hägg

My main research interest is human biological aging; how to measure it in human cohorts, understanding causal pathways in aging and identify geroprotectors to repurpose for age-related diseases. Markers of human biological aging can be telomere length, epigenetic clocks, functional aging, frailty index, etc. I study such markers in longitudinal data from several twin studies of aging (SATSA, GENDER, HARMONY, OCTO-Twin, TwinGene) within the Swedish Twin Registry and also using UK biobank data. Methods that I use include longitudinal modelling, causal analyses using drug target Mendelian Randomization, and large-scale genome-wide approaches.