Research Project Manager and Investigator, University of the Witwatersrand

Stuart Ali, BSc(Hons), MIoD, PhD, FRSPH, is Research Project Manager for the H3Africa AWI-Gen Collaborative Centre, and Investigator at the Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand in Johannesburg, South Africa.

His career has traversed diverse roles in molecular bioscience research, business development, and entrepreneurship. He co-founded an HIV clinical research center, has led EMEA sales, service and support functions for Thermo Life Science and Molecular Devices, and was Product Manager for high-throughput genotyping robotics at Robocon. Stuart has worked in several gene therapy and vaccine research laboratories including the Systemix Gene Therapy Laboratory at the Novartis Research Institute Vienna, Baxter Healthcare, Bioproducts and Bioengineering AG, Oxford University, and the University of the Witwatersrand.

Stuart’s research interests associate with precision medicine, tools for molecular diagnostics, big data and artificial intelligence, in the context of an holistic approach to improving the health of African populations.

Stuart lives in Johannesburg with his wife, several (!) cats, and two dogs named Matilda and Pandora.

Experience

  • 2016–present
    Researcher and Project Manager, Sydney Brenner Institute for Molecular Bioscience

Education

  •  
    Brunel University, PhD
  •  
    Brunel University, BSc (Hons)
  •  
    Henley College of Management, PG Diploma in Management

Publications

  • 2018
    AAV-mediated expression of sequences encoding broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex., submitted
  • 2018
    The burden of dyslipidaemia and factors associated with lipid levels among adults in rural northern Ghana: an AWI-Gen sub-study., submitted
  • 2018
    Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study. , Global Health Actions
  • 2018
    Regional patterns in the association between obesity and hypertension in Africa: Evidence from 30,044 participants in 13 countries. , submitted
  • 2018
    Lipid profiles and dyslipidemia in individuals aged 40-60 years across 6 sites in sub-Saharan Africa: findings from the H3Africa AWI-Gen Study., submitted
  • 2018
    Engineering a novel highly potent bispecific antibody iMab-CAP256 that targets HIV-1., in preparation
  • 2017
    Regional and sex differences in the prevalence and awareness of hypertension across 6 Sites in Sub-Saharan Africa: An H3Africa AWI-Gen Study., Global Heart
  • 2016
    H3Africa AWI-Gen Collaborative Centre: a resource to study the interplay between genomic and environmental risk factors for cardiometabolic diseases in four sub-Saharan African countries., Global Health, Epidemiology and Genomics
  • 2016
    The therapeutic application of CRISPR/Cas9 technologies for HIV. , Expert Opinion on Biological Therapy
  • 1999
    Circular dichroism analysis of insect cell expressed herpes simplex virus type I single-stranded DNA-binding protein ICP8. , Protein Expr. Purif.
  • 1999
    Immunological silencing of an antigenic peptide sequence engineered into the surface of a carrier protein. , FEBS Letters
  • 1999
    Transferrin Trojan Horses as a rational approach for the biological delivery of therapeutic peptide domains., J. Biol. Chem.
  • 1998
    High level expression and structural characterisation of herpes simplex virus type I transcriptional activator VP16 (alpha-trans inducing factor). , Biochem. Biophys. Res. Commun.
  • 1998
    Transferrin Trojan Horses: a novel approach for drug delivery ? , PhD Thesis
  • 1997
    Production of PCR-mimics for any semi-quantitative PCR application. , BioTechniques
  • 1997
    A rapid method for creating gene mutations and fusions using PCR- ligation-PCR mutagenesis. Invited book chapter., Gene Cloning and Analysis : current innovations’
  • 1996
    Resolution of all four transferrin isoforms generated during the iron binding process by multi-zone electrophoresis. , Analytical Biochemistry
  • 1996
    High yield production of functionally active human serum transferrin using a baculovirus expression system, and its structural characterization. , Biochemical Journal
  • 1995
    PCR-ligation-PCR mutagenesis : A protocol for creating gene fusions and mutations. , BioTechniques

Professional Memberships

  • Fellow of the Royal Society for Public Health
  • Member of the Institute of Directors
  • Member of the Project Management Institute