S. Olakunle Idowu is a Professor of Pharmaceutical Chemistry at the Faculty of Pharmacy, University of Ibadan. He holds a doctorate in Pharmaceutical Chemistry, specializing in Reagent Design and Assay Technologies. He played a pioneering role in the Alternative Method Development Initiative (AMDI) which is currently a strong research focus in the Department of Pharmaceutical Chemistry, University of Ibadan. His elegant postgraduate studies furnished a new chemical entity, the highly reactive aryldiazonium, 4-Carboxyl-2,6-dinitrobenzene diazonium (CDNBD), one of the most reactive aryldiazonium ever documented, which led to the award of the first doctorate in Pharmaceutical Chemistry at the University of Ibadan, in 1998. The reagent is now well established as a derivatizing reagent for drug analysis through chromophoric labelling in instrumental chemical analysis (digital colorimetry, UV-visible spectroscopy and liquid chromatography). His current research focus is Pharmaceutical Profiling and Informatics, leveraging Process Understanding, Modelling and Simulation to develop biorelevant assay technologies. Biorelevance of assay results has great potential for impact in lead optimization (drug discovery) and quality assurance of dietary supplements.