Tamara Terzian

My laboratory is dedicated to studying the regulation of the transcription factor p53. Mutations in p53 are found in more than 50% of human cancers, making this tumor suppressor the subject of extensive basic and preclinical research. Our studies focus on 3 main topics:

1- p53 in tumorigenesis: Through the utilization of mouse models of cancer, we to unravel the role of p53 mutations in driving tumorigenesis. By understanding the underlying mechanisms that initiate and promote skin cancers like squamous cell carcinomas and melanoma, we strive to enhance cancer therapies.

2- p53 and development: Our investigation involves studying mouse models that express elevated levels of p53, which exhibit developmental abnormalities, particularly lymphatic defects. By characterizing these mice phenotypically and molecularly, we aim to identify crucial factors contributing to the pathogenesis of associated diseases. Furthermore, we are exploring the potential of certain drugs in treating the debilitating disorder of lymphedema.

3- p53 and pigmentation: Our research focuses on the activation of the p53 pathway in skin stem cells with the goal of developing treatments for pigmentary disorders such as vitiligo and giant congenital nevi. We have identified a drug that targets the p53 pathway and shows promise in promoting melanocyte proliferation and repigmentation of depigmented vitiligo skin. We are currently analyzing the mode of action of this drug in preparation for future clinical trials.

These research areas represent our ongoing efforts to deepen our understanding of the working of p53 and contribute to the advancement of cancer and lymphatic disease therapy.