Senior NMR Spectroscopist, University of Bath

Bio

BSc Hons (1st) Inorganic Chemistry, University of Warwick 1994
PhD Inorganic Chemistry, University of Warwick 1998
Royal Society Visiting Fellow, Auckland University, New Zealand 1998-1999
Post Doctoral Research Officer, University of Leeds, UK, 1999-2000
Post Doctoral Research Officer, University of East Anglia, UK, 2000-2005
NMR Spectroscopist, University of Bath, UK, 2005 - 2014
Senior NMR Spectroscopist, University of Bath, UK, 2014 -

Research Interests
The role of alpha methyl acyl CoA racemase (AMACR/P504S) in prostate cancer. AMACR is an enzyme that is over-expressed in all cases of prostate cancer, and is currently of interest both as a better marker for the disease than the current prostate specific antigen (PSA) test and also as a potential target for inhibition by drug molecules. With Dr Matthew Lloyd, our research group of two PhD students is exploring the molecular biology of AMACR and attempting to identify high-throughput screening methods that will allow the isolation of potential inhibitors for this enzyme.
Use of diffusion ordered NMR spectroscopy (DOSY) and PCA to characterise complex mixtures. DOSY can be applied to complex mixtures to enable the identification of individual compounds with the population. PCA is a technique where large amounts of data are reduced to a set of more simple components, providing much information on how similar (or different) further samples are from these components. Projects involving these techniques include the characterization of seized drug samples and the properties and origins of wines and whiskies.

Experience

  • –present
    Senior NMR Spectroscopist, University of Bath