Up to 4,000 patients in England will be offered voxelotor to alleviate sickle cell symptoms.
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Articles on Sickle cell disease
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Sickle cell disease causes lower oxygen levels and abnormal blood flow in the brain, which can lead to a stroke. New research into noninvasive screening methods could help reduce the risk.
Many people with sickle cell disease don’t receive adequate treatment to ease their pain and are subjected to racial discrimination and stigmatization.
Among young children, adolescents and adult women, anemia strikes 1 in 3 globally. Most cases are driven by dietary iron deficiency, red blood cell disorders and untreated tropical diseases.
Following the controversial births of the first gene-edited babies, a major focus of the Third International Summit on Human Genome Editing was responsible use of CRISPR.
Molecular research is expensive, but worth it because of the burden of disease that it could relieve.
Life-saving blood is needed for everything from treating cancers and chronic conditions to helping trauma victims. But blood donations have dropped to crisis levels during the pandemic.
Evolutionary medicine uses our ancestral history to explain disease prevalence and inform care for conditions like Type 2 diabetes. It also challenges the bio-ethnocentrism of western medicine.
Today, human populations carry heavy genetic marks from the war with malaria. And it is the red blood cell (erythrocyte) that mostly bears the scars.
Once genetic lesions for diseases such as cystic fibrosis and haemophilia were identified, the idea of replacing or correcting defective genes grew into what we now call “gene therapy”.
Cystic fibrosis is the most common genetic disease among Caucasians. Now scientists believe they have discovered the origin of this often lethal genetic mutation and how it spread throughout Europe.
New research shows just 1% of E. coli bacteria’s genetic mutations are lethal.
Gene therapy is allowing us to switch on natural beneficial mutations to counteract the effects of negative mutations in diseases such as sickle cell anaemia.
Every year, 300,000 children are born with sickle-cell disease, primarily in Africa and India. It is a genetic disorder that causes some blood cells to become abnormally shaped. The result is that those…
Genetic mutations that affect our blood cells’ haemoglobin are the most common of all mutations. It has been estimated that around 5% of the world’s population carry a defective globin gene. Haemoglobin…
Top contributors
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Deputy Vice-Chancellor Academic Quality and Professor of Molecular Biology, UNSW Sydney
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Postdoctoral Fellow, Harvard University
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Division Head, Population Health and Immunity, WEHI (Walter and Eliza Hall Institute of Medical Research)
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Professor of Pediatrics and Population Health Sciences, University of Wisconsin-Madison
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Researcher and Scientific Writer at the Institute for Health Metrics and Evaluation, University of Washington
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Professor, Applied Evolutionary Ecology, Laurentian University
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Eugene M. Isenberg Chair in Integrative Studies, UMass Amherst
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PhD Candidate, Biomolecular Sciences, Laurentian University
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Senior lecturer in Molecular Pathology and Microbial Genetics, University of Nigeria
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Assistant Professor of Biomedical Engineering, Kennesaw State University
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Researcher in Neonatal and Child Health at the Institute for Health Metrics and Evaluation, University of Washington
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Associate Senior Lecturer, Division of Molecular Medicine and Gene Therapy, Lund University
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Professor of Bioinformatics, Rochester Institute of Technology
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Adjunct Professor in Health Metrics Sciences and Professor of Anesthesiology and Pain Medicine, University of Washington
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Graduate Student - Department of Psychology, Laurentian University
